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Titolo:
HNMP-1 - A NOVEL HEMATOPOIETIC AND NEURAL MEMBRANE-PROTEIN DIFFERENTIALLY REGULATED IN NEURAL DEVELOPMENT AND INJURY
Autore:
BOLIN LM; MCNEIL T; LUCIAN LA; DEVAUX B; FRANZBACON K; GORMAN DM; ZURAWSKI A; MURRAY R; MCCLANAHAN TK;
Indirizzi:
DNAX RES INST MOLEC & CELLULAR BIOL INC,901 CALIF AVE PALO ALTO CA 94304 DNAX RES INST MOLEC & CELLULAR BIOL INC PALO ALTO CA 94304
Titolo Testata:
The Journal of neuroscience
fascicolo: 14, volume: 17, anno: 1997,
pagine: 5493 - 5502
SICI:
0270-6474(1997)17:14<5493:H-ANHA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
MARIE-TOOTH DISEASE; PERIPHERAL MYELIN PROTEIN-22; IL-6 SIGNAL TRANSDUCER; TREMBLER MUTANT MICE; SCIATIC-NERVE INJURY; ARREST-SPECIFIC GENE; DORSAL-ROOT GANGLIA; STEM-CELL FACTOR; SCHWANN-CELLS; MOLECULAR-GENETICS;
Keywords:
SCHWANN CELL; DRG; SENSORY NEURON; MOTONEURON; REGENERATION; PMP22; HEMATOPOIESIS; DEVELOPMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
70
Recensione:
Indirizzi per estratti:
Citazione:
L.M. Bolin et al., "HNMP-1 - A NOVEL HEMATOPOIETIC AND NEURAL MEMBRANE-PROTEIN DIFFERENTIALLY REGULATED IN NEURAL DEVELOPMENT AND INJURY", The Journal of neuroscience, 17(14), 1997, pp. 5493-5502

Abstract

The hnmp-1 (hematopoietic neural membrane protein) gene encodes a protein with striking similarity to the tetra-transmembrane-spanning protein encoded by pmp22. hnmp-1 was cloned from an elutriated human monocyte library and is expressed in various human hematopoietic and lymphoid lineages as well as adult mouse spleen and thymus. In the mouse nervous system, HNMP-1 mRNA is temporally expressed by Schwann cells during sciatic nerve myelination. Dorsal root ganglia sensory and spinal cord alpha-motoneurons acquire HNMP-1 protein selectively throughout development. In the fiber tracts of the spinal card and in sciatic nerve, HNMP-1 protein is axon-associated, Additionally a rapid and sustained level of HNMP-1 expression is observed in response to acute PNS injury. HNMP-1 is constituitively induced in sciatic nerve of Trembler J mice, which are mutant for pmp22 and have a demyelinating/hypomyelinating phenotype. The expression pattern of HNMP-1 suggests a possible role for this molecule during active myelination.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 02:45:19