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Titolo:
PLASMA L-ARGININE CONCENTRATIONS IN PREMATURE-INFANTS WITH NECROTIZING ENTEROCOLITIS
Autore:
ZAMORA SA; AMIN HJ; MCMILLAN DD; KUBES P; FICK GH; BUTZNER JD; PARSONS HG; SCOTT RB;
Indirizzi:
UNIV CALGARY,HLTH SCI CTR,DEPT PEDIAT,3330 HOSP DR NW CALGARY AB T2N 4N1 CANADA UNIV CALGARY,HLTH SCI CTR,DEPT PEDIAT CALGARY AB T2N 4N1 CANADA UNIV CALGARY,DEPT COMMUNITY HLTH SCI CALGARY AB T2N 4N1 CANADA UNIV CALGARY,DEPT PHYSIOL CALGARY AB T2N 4N1 CANADA UNIV CALGARY,DIV GASTROENTEROL CALGARY AB T2N 4N1 CANADA UNIV CALGARY,DIV NEONATOL CALGARY AB T2N 4N1 CANADA
Titolo Testata:
The Journal of pediatrics
fascicolo: 2, volume: 131, anno: 1997,
pagine: 226 - 232
SICI:
0022-3476(1997)131:2<226:PLCIPW>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMINO-ACID SUPPLEMENTATION; PLATELET-ACTIVATING-FACTOR; ENDOGENOUS NITRIC-OXIDE; MUCOSAL PERMEABILITY; DEVELOPING PIGLETS; PRETERM INFANTS; INJURY; ISCHEMIA; RAT; HYPERAMMONEMIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
S.A. Zamora et al., "PLASMA L-ARGININE CONCENTRATIONS IN PREMATURE-INFANTS WITH NECROTIZING ENTEROCOLITIS", The Journal of pediatrics, 131(2), 1997, pp. 226-232

Abstract

Objective: To determine whether L-arginine concentrations (the substrate for nitric oxide synthesis) are lower in premature infants in whomnecrotizing enterocolitis (NEC) develops than in unaffected infants. Methods: We measured arginine and nutritional intake, plasma arginine,glutamine, total amino acids, and ammonia concentrations in 53 premature infants (mean gestational age +/- SD: 27 +/- 1.7 weeks) at risk ofNEC. Measurements were done on days 3, 7, 14 and 21 and just before treatment in infants with NEC. Results: Necrotizing enterocolitis developed in 11 infants between postnatal days 1 and 26. On day 3, plasma arginine concentrations were decreased compared with normal published values (mean +/- SE, 41 mu mol/L +/- 4). Arginine concentrations increased with day of life of measurement (p < 0.001) and arginine intake (p< 0.001). Plasma arginine concentrations were significantly lower at the time of diagnosis in infants with NEC compared with control subjects, even after adjusting for arginine intake and day of life (p = 0.032). Plasma glutamine and total amino acid concentrations were not significantly different in infants with NEC compared with control subjects. Plasma ammonia concentrations were elevated on day 3 (mean +/- SE, 72 +/- 3.3 mu mol/L) and decreased with postnatal age (p < 0.001) and increasing plasma arginine concentrations (p < 0.001). Conclusion: Plasma arginine concentrations are decreased at the time of diagnosis in premature infants with NEC. The potential benefit of arginine supplementation in the prevention of the disease deserves evaluation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 00:56:53