Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
EFFECTS OF ATRIAL DILATATION ON REFRACTORY PERIOD AND VULNERABILITY TO ATRIAL-FIBRILLATION IN THE ISOLATED LANGENDORFF-PERFUSED RABBIT HEART
Autore:
RAVELLI F; ALLESSIE M;
Indirizzi:
UNIV LIMBURG,CARDIOVASC RES INST MAASTRICHT,DEPT PHYSIOL,POB 616 NL-6200 MD MAASTRICHT NETHERLANDS UNIV LIMBURG,CARDIOVASC RES INST MAASTRICHT,DEPT PHYSIOL NL-6200 MD MAASTRICHT NETHERLANDS CTR MAT & BIOFIS MED TRENT ITALY
Titolo Testata:
Circulation
fascicolo: 5, volume: 96, anno: 1997,
pagine: 1686 - 1695
SICI:
0009-7322(1997)96:5<1686:EOADOR>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONTRACTION-EXCITATION FEEDBACK; ACUTE VENTRICULAR DILATATION; MONOPHASIC ACTION-POTENTIALS; MECHANOELECTRICAL FEEDBACK; STRETCH; ARRHYTHMIAS; MYOCARDIUM; PRESSURE; MYOCYTES; HUMANS;
Keywords:
FIBRILLATION; TACHYARRHYTHMIAS; ACTION POTENTIALS; PRESSURE; ATRIUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
F. Ravelli e M. Allessie, "EFFECTS OF ATRIAL DILATATION ON REFRACTORY PERIOD AND VULNERABILITY TO ATRIAL-FIBRILLATION IN THE ISOLATED LANGENDORFF-PERFUSED RABBIT HEART", Circulation, 96(5), 1997, pp. 1686-1695

Abstract

Background Atrial fibrillation (AF) is frequently observed under conditions that are associated with atrial dilatation. The aim of this study was to investigate the effects of atrial dilatation on the substrate of AF. Methods and Results In 15 Langendorff-perfused rabbit hearts,the interatrial septum was perforated, and after occlusion of the caval and pulmonary veins, biatrial pressure was increased by raising thelevel of an outflow cannula in the pulmonary artery. Right and left atrial effective refractory periods (AERPs), monophasic action potentials (MAPs), and inducibility of AF by single premature stimuli were measured as a function of atrial pressure. Increasing the atrial pressurefrom 0.5+/-0.7 to 16.2+/-2.2 cm H2O resulted in a progressive shortening of the right AERP from 82.2+/-9.8 to 48.0+/-5.1 ms. In the left atrium, an increase in pressure up to 7.4+/-0.3 cm H2O had no effect on the AERP. At higher pressures, however, the left AERP also shortened, from 67.5+/-7.5 to 49.3+/-2.0 ms, The duration of MAPs also decreased by an increase in atrial pressure, showing a high correlation with theshortening in AERP (r=.94, P<.01). All these changes were completely reversible within 3 minutes after release of the atrial stretch. Dilatation of the atria was a major determinant for the vulnerability to AF. The inducibility of AF increased from 0% al low pressures to 100% when the atrial pressure was >10 cm H2O. Release of the atrial wall stress resulted in prompt cardioversion of AF. The increased vulnerabilityfor AF was highly correlated with the shortening in AERP (logistic regression r=.97). No correlation was found with the spatial dispersion between right and left AERPs. Conclusions Increased atrial pressure inthe isolated rabbit heart resulted in a significant increase in vulnerability to AF that was closely correlated to shortening of the AERP. These changes were completely reversible within 3 minutes after release of the atrial stretch, resulting in prompt termination of AF.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 22:06:49