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Titolo:
CIRCADIAN-RHYTHMS OF CARDIOVASCULAR FUNCTIONS ARE MODULATED BY THE BAROREFLEX AND THE AUTONOMIC NERVOUS-SYSTEM IN THE RAT
Autore:
MAKINO M; HAYASHI H; TAKEZAWA H; HIRAI M; SAITO H; EBIHARA S;
Indirizzi:
NAGOYA UNIV,SCH MED,DEPT INTERNAL MED 1,DIV CARDIOL,SHOWA KU,65 TSURUMAI NAGOYA AICHI 466 JAPAN NAGOYA UNIV,SCH MED,DEPT INTERNAL MED 1,DIV CARDIOL,SHOWA KU NAGOYA AICHI 466 JAPAN NAGOYA UNIV,SCH AGR SCI,DEPT ANIM PHYSIOL NAGOYA AICHI 466 JAPAN
Titolo Testata:
Circulation
fascicolo: 5, volume: 96, anno: 1997,
pagine: 1667 - 1674
SICI:
0009-7322(1997)96:5<1667:COCFAM>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-PRESSURE VARIATIONS; HEART-RATE; SUPRACHIASMATIC LESIONS; HYPERTENSIVE RATS; ARTERIAL-PRESSURE; DENERVATED RATS; SYMPATHECTOMY; VARIABILITY; GUANETHIDINE; FREQUENCY;
Keywords:
CIRCADIAN RHYTHM; BARORECEPTORS; BLOOD PRESSURE; NERVOUS SYSTEM, AUTONOMIC;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
M. Makino et al., "CIRCADIAN-RHYTHMS OF CARDIOVASCULAR FUNCTIONS ARE MODULATED BY THE BAROREFLEX AND THE AUTONOMIC NERVOUS-SYSTEM IN THE RAT", Circulation, 96(5), 1997, pp. 1667-1674

Abstract

Background We assessed the hypothesis that the baroreflex and the autonomic nervous system are important in the control of the circadian rhythms of cardiovascular functions. Methods and Results We continuouslymeasured blood pressure (BP), heart rate (HR); and locomotor activityin sinoaortic denervated (SAD), sympathectomized, and atropine-injected rats by use of a radiotelemetry system. The circadian rhythm of mean blood pressure (MBP) was selectively disrupted in SAD rats under 12-hour light-dark (LD12:12) cycles as a result of an increase in MBP during the light period and disappeared under constant darkness (DD). Thelocomotor activity and HR were not remarkably affected by SAD. The circadian rhythm of MBP was suppressed in sympathectomized rats by a decrease in the MBP during the dark period, and the abrupt changes in MBPwhen the lighting was altered were not seen under LD. Under DD, an MBP rhythm similar to that observed under LD was obtained. Sympathectomized rats also showed lower HR levels during the dark period than intact rats under LD cycles. In atropine-injected rats, the MBP and HR increased, especially during the light period, resulting in a reduction oflight-dark differences in MBP and HR. The locomotor activity showed an apparent 24-hour variation in the sympathectomized and atropine-injected rats. Conclusions The disruption of the baroreflex selectively eliminates the circadian rhythm of BP, and the circadian rhythms of BP and HR are modulated by the autonomic nervous system in rats. The circadian rhythms of BP and HR are regulated by different mechanisms involving the autonomic nervous system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 06:24:38