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Titolo:
GLOBAL-ISCHEMIA INDUCES DOWN-REGULATION OF GLUR2 MESSENGER-RNA AND INCREASES AMPA RECEPTOR-MEDIATED CA2+ INFLUX IN HIPPOCAMPAL CA1 NEURONS OF GERBIL
Autore:
GORTER JA; PETROZZINO JJ; ARONICA EM; ROSENBAUM DM; OPITZ T; BENNETT MVL; CONNOR JA; ZUKIN RS;
Indirizzi:
YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT NEUROSCI,1300 MORRIS PK AVE BRONX NY 10461 YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT NEUROSCI BRONX NY 10461 ROCHE INST MOL BIOL,ROCHE RES CTR NUTLEY NJ 07110
Titolo Testata:
The Journal of neuroscience
fascicolo: 16, volume: 17, anno: 1997,
pagine: 6179 - 6188
SICI:
0270-6474(1997)17:16<6179:GIDOGM>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSIENT FOREBRAIN ISCHEMIA; GLUTAMATE-GATED CHANNELS; CEREBRAL-ISCHEMIA; GENE-EXPRESSION; RAT HIPPOCAMPUS; SELECTIVE VULNERABILITY; CALCIUM PERMEABILITY; NEOCORTICAL NEURONS; SUBUNIT COMPOSITION; ACID RECEPTORS;
Keywords:
GLOBAL ISCHEMIA; GLUTAMATE RECEPTOR REGULATION; AMPA RECEPTOR; GLUR2; GLURB; HIPPOCAMPUS; CA1; INTRACELLULAR CALCIUM; INTRACELLULAR RECORDING; NEURODEGENERATION; DELAYED NEURODEGENERATION; OPTICAL IMAGING; GERBIL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
62
Recensione:
Indirizzi per estratti:
Citazione:
J.A. Gorter et al., "GLOBAL-ISCHEMIA INDUCES DOWN-REGULATION OF GLUR2 MESSENGER-RNA AND INCREASES AMPA RECEPTOR-MEDIATED CA2+ INFLUX IN HIPPOCAMPAL CA1 NEURONS OF GERBIL", The Journal of neuroscience, 17(16), 1997, pp. 6179-6188

Abstract

Transient, severe forebrain or global ischemia leads to delayed cell death of pyramidal neurons in the hippocampal CA1. The precise molecular mechanisms underlying neuronal cell death after global ischemia areas yet unknown. Glutamate receptor-mediated Ca2+ influx is thought toplay a critical role in this cell death. In situ hybridization revealed that the expression of rRNA encoding GluR2 (the subunit that limitsCa2+ permeability of AMPA-type glutamate receptors) was markedly and specifically reduced in gerbil CA1 pyramidal neurons after global ischemia but before the onset of neurodegeneration. To determine whether the change in GluR2 expression is functionally significant, we examinedthe AMPA receptor-mediated rise in cytoplasmic free Ca2+ level ([Ca2+](i)) in individual CA1 pyramidal neurons by optical imaging with the Ca2+ indicator dye fura-2 and by intracellular recording, Seventy-two hours after ischemia, CA1 neurons that retained the ability to fire action potentials exhibited a greatly enhanced AMPA-elicited rise in [Ca2+](i). Basal [Ca2+](i) in these neurons was unchanged, These findingsprovide evidence for Ca2+ entry directly through AMPA receptors in pyramidal neurons destined to die, Downregulation of GluR2 gene expression and an increase in Ca2+ influx through AMPA receptors in response to endogenous glutamate are likely to contribute to the delayed neuronal death after global ischemia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 21:04:26