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Titolo:
HUMAN PLASMA-ALBUMIN TRANSPORTS [C-13]DOCOSAHEXAENOIC ACID IN 2 LIPIDFORMS TO BLOOD-CELLS
Autore:
BROSSARD N; CROSET M; NORMAND S; POUSIN J; LECERF J; LAVILLE M; TAYOT JL; LAGARDE M;
Indirizzi:
INSA,INSERM,U352 VILLEURBANNE FRANCE INSA,INSERM,U352 VILLEURBANNE FRANCE FAC MED R LAENNEC,INSERM,U449 LYON FRANCE INSA,CNRS,UMR 5585,LAB MODELISAT MATH & CALCUL SCI VILLEURBANNE FRANCE IMEDEX,ZI TROQUES CHAPONOST FRANCE
Titolo Testata:
Journal of lipid research
fascicolo: 8, volume: 38, anno: 1997,
pagine: 1571 - 1582
SICI:
0022-2275(1997)38:8<1571:HPT[AI>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
N-3 FATTY-ACIDS; DOCOSAHEXAENOIC ACID; EICOSAPENTAENOIC ACID; PLATELET PHOSPHOLIPIDS; FISH OILS; RAT-BRAIN; METABOLISM; ACYLTRANSFERASE; LIPOPROTEIN; RETINA;
Keywords:
N-3 FATTY ACID; STABLE ISOTOPE; PLATELETS; LEUKOCYTES; ERYTHROCYTES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
N. Brossard et al., "HUMAN PLASMA-ALBUMIN TRANSPORTS [C-13]DOCOSAHEXAENOIC ACID IN 2 LIPIDFORMS TO BLOOD-CELLS", Journal of lipid research, 38(8), 1997, pp. 1571-1582

Abstract

Docosahexaenoic acid (22:6) decreases blood platelet function and is highly concentrated in the brain where its depletion leads to functional impairments. Because the platelets and blood brain barrier capillary endothelium cannot hydrolyze the complex lipids for fatty acid (FA) uptake, nonesterified FA (NEFA) bound to albumin are assumed to be thedelivery route of FA to these cells. The supply of C-13-labeled 22:6 to blood cells by plasma albumin was studied in humans after a single ingestion of this FA esterified in a triglyceride (TG). The 22:6 C-13/C-12 ratio, measured by gas chromatography combustion-isotope ratio mass spectrometry was measured in lipid classes from albumin, platelets,leukocytes, and erythrocytes (taken as a tentative index of the brainuptake). Nonesterified [C-13]22:6 bound to albumin was rapidly produced after ingestion, as a result of the hydrolysis of very low density lipoprotein (VLDL) plus chylomicron TG. We found that albumin carried another source of 22:6, lyso-phosphatidylcholines (lyse-PC), in which [C-13]22:6 accumulated while the nonesterified [C-13] 22:6 reached itsminimal plasma concentrations. Computation of the relative contribution of NEFA and lyse-PC for the [C-13] 22:6 delivery to platelets and erythrocytes showed that the [C-13]22:6 supply to platelets occurred uniquely through NEFA, whereas this pool was weakly involved in the delivery to erythrocytes. In contrast, lyse-PC was uniquely concerned withthe 22:6 delivery to erythrocytes and represented the major part of this supply. We conclude that plasma albumin carries 22:6 in two lipid forms that are involved differently in the delivery of this FA to target cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 04:47:11