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Titolo:
MULTIPLE T-CELL EXPANSIONS ARE FOUND IN THE BLOOD AND SYNOVIAL-FLUID OF PATIENTS WITH REACTIVE ARTHRITIS
Autore:
ALLEN RL; GILLESPIE GMA; HALL F; EDMONDS S; HALL MA; WORDSWORTH BP; MCMICHAEL AJ; BOWNESS P;
Indirizzi:
JOHN RADCLIFFE HOSP,INST MOL MED OXFORD OX3 9DS ENGLAND UNIV OXFORD,MOL IMMUNOL GRP OXFORD ENGLAND WEXHAM PK HOSP SLOUGH SL2 4HL BERKS ENGLAND
Titolo Testata:
Journal of rheumatology
fascicolo: 9, volume: 24, anno: 1997,
pagine: 1750 - 1757
SICI:
0315-162X(1997)24:9<1750:MTEAFI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE CHAIN-REACTION; TOXIC-SHOCK SYNDROME; TCR BETA-CHAIN; YERSINIA-ENTEROCOLITICA; CHLAMYDIA-TRACHOMATIS; MONOCLONAL-ANTIBODIES; ANKYLOSING-SPONDYLITIS; RHEUMATOID-ARTHRITIS; CLONAL POPULATIONS; ANTIGEN RECEPTOR;
Keywords:
REACTIVE ARTHRITIS; MONOCLONAL ANTIBODY; T LYMPHOCYTE; T CELL RECEPTOR; CD8; CD4;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
R.L. Allen et al., "MULTIPLE T-CELL EXPANSIONS ARE FOUND IN THE BLOOD AND SYNOVIAL-FLUID OF PATIENTS WITH REACTIVE ARTHRITIS", Journal of rheumatology, 24(9), 1997, pp. 1750-1757

Abstract

Objective. To look for evidence of T lymphocyte expansions in the blood and synovial fluid (SF) of patients with reactive arthritis (ReA). Methods. Paired peripheral blood and synovial samples from 10 patientswith ReA were studied by dual color flow cytometry using T cell receptor (TCR) V beta specific and CD4 or CD8 specific antibodies. Two synovial CD8 expansions were studied by 3 color flow cytometry. Peripheralblood samples from 13 healthy, age matched individuals were studied as controls. Results. Statistically significant expansions were observed in all patients, occurring in blood and SF CD4 and CD8 compartments,but were most common in the synovial CD8 compartment. Expansions studied in further detail displayed an activated ''memory'' phenotype. A synovial BV22S1/CD8 expansion was seen in 5/6 patients with sexually acquired ReA. Conclusion. Multiple T lymphocyte expansions are found in both the blood and SF of patients with ReA. Expansions were most commonly found in the synovial CD8 compartment, where they appeared to express both activation and memory markers, This indicates that T lymphocytes (and in particular cytotoxic T cells) may play a pathogenic role in ReA. These findings are consistent with either an antigen or a superantigen driven response.

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Documento generato il 04/12/20 alle ore 22:37:02