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Titolo:
CYTOKINE-STIMULATED AND VIRUS-STIMULATED AIRWAY SMOOTH-MUSCLE CELLS PRODUCE IL-11 AND OTHER IL-6-TYPE CYTOKINES
Autore:
ELIAS JA; WU Y; ZHENG T; PANETTIERI R;
Indirizzi:
YALE UNIV,SCH MED,DEPT INTERNAL MED,PULM & CRIT CARE MED SECT,333 CEDAR ST,LCI 105 NEW HAVEN CT 06520 HOSP UNIV PENN,DIV PULM & CRIT CARE PHILADELPHIA PA 19104
Titolo Testata:
American journal of physiology. Lung cellular and molecular physiology
fascicolo: 3, volume: 17, anno: 1997,
pagine: 648 - 655
SICI:
1040-0605(1997)17:3<648:CAVASC>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEUKEMIA INHIBITORY FACTOR; IN-VITRO; INDUCTION; PROLIFERATION; EXPRESSION; RECEPTOR; INTERLEUKIN-11; ASTHMA; BETA; INFLAMMATION;
Keywords:
INTERLEUKIN-6; INTERLEUKIN-11; LEUKEMIA INHIBITORY FACTOR; HUMAN AIRWAY SMOOTH MUSCLE CELL; ASTHMA; RESPIRATORY SYNCYTIAL VIRUS; PARAINFLUENZA VIRUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
J.A. Elias et al., "CYTOKINE-STIMULATED AND VIRUS-STIMULATED AIRWAY SMOOTH-MUSCLE CELLS PRODUCE IL-11 AND OTHER IL-6-TYPE CYTOKINES", American journal of physiology. Lung cellular and molecular physiology, 17(3), 1997, pp. 648-655

Abstract

Inflammation and smooth muscle abnormalities coexist in human airway disorders, and inflammation modulates the proliferative and contractile properties of airway smooth muscle cells. To determine whether humanairway smooth muscle (HASM) cells have the ability to regulate local inflammatory processes, we characterized the interleukin (IL)-6-type cytokine production of HASM cells in vitro. We demonstrated that HASM cells are potent producers of IL-11 when stimulated with IL-1 or transforming growth factor-beta 1 (TGF-beta 1) and that IL-11 levels are synergistically increased by IL-1 and TGF-beta 1 in combination. These studies also demonstrated that IL-l and TGF-beta 1-stimulated HASM cellsproduce IL-6 and leukemia inhibitory factor but not oncostatin M and that respiratory syncytial virus and parainfluenza virus type 3 stimulate HASM cell IL-11 production. Finally, they demonstrate that, in allcases, the stimulation of HASM cell IL-11 elaboration is pretranslationally mediated since cytokine- and virus-induced alterations in IL-11protein production were associated with proportionate changes in IL-11 mRNA accumulation. HASM cells are potent producers of IL-ll and other IL-6-type cytokines and may be important regulators of local airway inflammation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 20:07:59