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Titolo:
MARKERS OF MAST-CELL DEGRANULATION
Autore:
HOGAN AD; SCHWARTZ LB;
Indirizzi:
VIRGINIA COMMONWEALTH UNIV,DIV RHEUMATOL ALLERGY & IMMUNOL,DEPT INTERNAL MED RICHMOND VA 23298
Titolo Testata:
Methods
fascicolo: 1, volume: 13, anno: 1997,
pagine: 43 - 52
SICI:
1046-2023(1997)13:1<43:MOMD>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXERCISE-INDUCED ASTHMA; INFANT-DEATH-SYNDROME; PLASMA HISTAMINE; SYSTEMIC MASTOCYTOSIS; HUMAN TRYPTASE; MONOCLONAL-ANTIBODIES; COT DEATH; ANAPHYLACTOID REACTIONS; RADIOENZYMATIC ASSAY; ENZYME-IMMUNOASSAY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
94
Recensione:
Indirizzi per estratti:
Citazione:
A.D. Hogan e L.B. Schwartz, "MARKERS OF MAST-CELL DEGRANULATION", Methods, 13(1), 1997, pp. 43-52

Abstract

Mast cells are the primary effector cells of immediate hypersensitivity reactions in humans. Upon mast cell activation both preformed and newly synthesized mediators are secreted. Histamine can be measured by fluorometric assays, radioenzymatic assays, and immunoassays. These methods have been applied to plasma and urine to detect histamine that had been released in vivo and to release histamine in vitro from basophils and mast cells. Another mast cell constituent is tryptase, which is a more selective marker of mast cells, because negligible amounts are found in basophils. beta-Tryptase is stored in secretory granules and is actively released when mast cells degranulate. alpha-Protryptase remains in the proenzyme form and is constitutively released from mastcells, and consequently its level in serum reflects total numbers of mast cells. alpha-Protryptase levels are elevated in serum at baselinein subjects with systemic mastocytosis, whereas beta-tryptase is elevated in serum from subjects with systemic anaphylaxis. These markers serve as precise clinical indicators of the involvement of mast cells in human disease. (C) 1997 Academic Press.

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Documento generato il 23/01/21 alle ore 02:55:47