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Titolo:
ROLE OF TACHYKININS IN OZONE-INDUCED AIRWAY HYPERRESPONSIVENESS TO CIGARETTE-SMOKE IS GUINEA-PIGS
Autore:
WU ZX; MORTON RF; LEE LY;
Indirizzi:
UNIV KENTUCKY,DEPT PHYSIOL,800 ROSE ST LEXINGTON KY 40536 UNIV KENTUCKY,DEPT PHYSIOL LEXINGTON KY 40536
Titolo Testata:
Journal of applied physiology
fascicolo: 3, volume: 83, anno: 1997,
pagine: 958 - 965
SICI:
8750-7587(1997)83:3<958:ROTIOA>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
PULMONARY C-FIBERS; SUBSTANCE-P; INDUCED BRONCHOCONSTRICTION; NEUTRAL ENDOPEPTIDASE; DOGS; HYPERREACTIVITY; MECHANISMS; REFLEXES; RELEASE; LUNGS;
Keywords:
NEUROKININ RECEPTOR ANTAGONISTS; BRONCHOPULMONARY C-FIBERS; INHALED IRRITANTS NEUROKININ A; SUBSTANCE P; BRONCHOCONSTRICTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
Z.X. Wu et al., "ROLE OF TACHYKININS IN OZONE-INDUCED AIRWAY HYPERRESPONSIVENESS TO CIGARETTE-SMOKE IS GUINEA-PIGS", Journal of applied physiology, 83(3), 1997, pp. 958-965

Abstract

Acute exposure to ozone (O-3) induces airway hyperresponsiveness to various inhaled bronchoactive substances. Inhalation of cigarette smoke, a common inhaled irritant in humans, is known to evoke a transient bronchoconstrictive effect. To examine whether O-3 increases airway responsiveness to cigarette smoke, effects of smoke inhalation challenge on total pulmonary resistance (RL) and dynamic lung compliance (Cdyn) were compared before and after exposure to O-3 (1.5 ppm, 1 h) in anesthetized guinea pigs. Before O-3 exposure, inhalation of two breaths ofcigarette smoke (7 ml) at a low concentration (33%) induced a mild and reproducible bronchoconstriction that slowly developed and reached its peak (Delta RL = 67 +/- 19%, Delta Cdyn = -29 +/- 6%) after a delayof >1 min. After exposure to O-3 the same cigarette smoke inhalation challenge evoked an intense bronchoconstriction that occurred more rapidly, reaching its peak (Delta RL = 620 +/- 224%, Delta Cdyn = -35 +/-7%) within 20 s, and was sustained far >2 min. By contrast, sham exposure to room air did not alter the bronchomotor response to cigarette smoke challenge. Pretreatment with CP-99994 and SR-48968, the selective antagonists of neurokinin type 1 and 2 receptors, respectively, completely blocked the enhanced responses of RL and Cdyn to cigarette smoke challenge induced by O-3. These results show that O-3 exposure induces airway hyperresponsive ness to inhaled cigarette smoke and that theenhanced responses result primarily from the bronchoconstrictive effect of endogenous tachykinins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 03:33:17