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Titolo:
WORK IN DRY-CLEANING AND THE INCIDENCE OF CANCER OF THE ORAL CAVITY, LARYNX, AND ESOPHAGUS
Autore:
VAUGHAN TL; STEWART PA; DAVIS S; THOMAS DB;
Indirizzi:
FRED HUTCHINSON CANC RES CTR,PROGRAM EPIDEMIOL MP474,1124 COLUMBIA STSEATTLE WA 98104 FRED HUTCHINSON CANC RES CTR,PROGRAM EPIDEMIOL MP474 SEATTLE WA 98104 UNIV WASHINGTON,DEPT EPIDEMIOL SEATTLE WA 98195 NCI,EPIDEMIOL & BIOSTAT PROGRAM ROCKVILLE MD 00000
Titolo Testata:
Occupational and environmental medicine
fascicolo: 9, volume: 54, anno: 1997,
pagine: 692 - 695
SICI:
1351-0711(1997)54:9<692:WIDATI>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
OCCUPATIONAL EXPOSURE; PERCHLOROETHYLENE EXPOSURE; RISK-FACTORS; TETRACHLOROETHYLENE; CLEANERS; INDUSTRY; SHOPS;
Keywords:
NEOPLASMS; LARYNX; ORAL CAVITY; ESOPHAGEAL; GASTRIC CARDIA; ADENOCARCINOMA; DRY CLEANING; PERCHLOROETHYLENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
T.L. Vaughan et al., "WORK IN DRY-CLEANING AND THE INCIDENCE OF CANCER OF THE ORAL CAVITY, LARYNX, AND ESOPHAGUS", Occupational and environmental medicine, 54(9), 1997, pp. 692-695

Abstract

Objectives-To investigate whether employment in dry cleaning, and potential exposure to perchloroethylene (PCE), were associated with increased risk of carcinoma of the oral cavity and pharynx, larynx, oesophagus, and gastric cardia. Methods-Two population based case-control studies were carried out. There were 491 cases of carcinoma of the oral cavity and pharynx, 235 of the larynx, and 404 of the oesophagus and gastric cardia. 724 controls were selected by random digit dialing. Personal interviews ascertained information on lifetime job histories, cigarette use, alcohol consumption, and other potential risk factors. Theprobability and level of exposure to PCE were estimated from the scientific literature. Results-People who worked in dry cleaning tended toconsume less alcohol and cigarettes than the general population. The adjusted odds ratio (OR) associated with ever having worked in dry cleaning was 1.6 (95% confidence interval (95% CI) = 0.6 to 4.4) for all cancer types together. The strongest associations were with laryngeal (OR 2.7; 95% CI 0.6 to 10.9) and oesophageal squamous cell carcinomas (OR 3.6; 95% CI 0.5 to 27.0). For laryngeal cancer, the relative risk increased with number of years employed in the dry cleaning industry (P = 0.14. The two cases of oesophageal squamous cell carcinomas had worked in dry cleaning for only a short time. Analyses of subsites showed higher risks for supraglottic laryngeal cancer (OR 5.7; 95% CI 1.0 to 32.1) and cancer of the tongue (OR 2.3; 95% CI 0.4 to 12.6). Analyses of exposure to PCE yielded similar results. Conclusions-These findings could easily be explained by chance; nevertheless, they are consistent with previous reports of excess risk of oesophageal, laryngeal, and tongue cancer, and suggest that previous studies of dry cleaners that could not control for alcohol and cigarette use may have underestimated the relative risks of such cancers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 20:03:16