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Titolo:
SURVIVAL RATE IMPROVEMENT IN A RAT ISCHEMIA MODEL BY LONG CIRCULATINGLIPOSOMES CONTAINING CYTIDINE-5'-DIPHOSPHATE CHOLINE
Autore:
FRESTA M; PUGLISI G;
Indirizzi:
UNIV CATANIA,DIPARTIMENTO SCI FARMACEUT,VIALE A DORIA 6 I-95125 CATANIA ITALY
Titolo Testata:
Life sciences
fascicolo: 13, volume: 61, anno: 1997,
pagine: 1227 - 1235
SICI:
0024-3205(1997)61:13<1227:SRIIAR>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL POSTISCHEMIC REPERFUSION; PHOSPHOLIPID-VESICLES; CDP-CHOLINE; MULTILAMELLAR; EFFICIENCY; ENTRAPMENT;
Keywords:
LIPOSOMES; CYTIDINE-5(I)-DIPHOSPHATE CHOLINE; ISCHEMIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
M. Fresta e G. Puglisi, "SURVIVAL RATE IMPROVEMENT IN A RAT ISCHEMIA MODEL BY LONG CIRCULATINGLIPOSOMES CONTAINING CYTIDINE-5'-DIPHOSPHATE CHOLINE", Life sciences, 61(13), 1997, pp. 1227-1235

Abstract

Unilamellar liposomes made up of DPPC-DPPS-Chol (7:4:7 molar ratio) and ganglioside G(M1) 8% mol were used to deliver cytidine-5(I)-diphosphate choline (CDP-choline) to the brain. The liposomal suspension consisted of unilamellar vesicles with a mean size of 50 nm and a very narrow size distribution. The therapeutic effectiveness of CDP-choline-loaded liposomes was investigated by an in vivo model of cerebral ischemia on Wistar rats (320-350 g). The animals were made ischemic to different extents (5, 15 and 30 min) by bilateral clamping of the common carotid arteries. The effect of free and liposomally encapsulated CDP-choline on the survival rate of post-ischemic reperfused rats was evaluated. The liposome formulation was much more active against ischemic injury than the free CDP-choline, ensuring a noticeable improvement of the survival rate with regards to the free drug ranging from 45% to 100% as a function of the duration of the ischemic event.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 10:47:29