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Titolo:
STOICHIOMETRIES OF AMPA RECEPTOR SUBUNIT MESSENGER-RNAS IN RAT-BRAIN FALL INTO DISCRETE CATEGORIES
Autore:
GOLD SJ; AMBROSINGERSON J; HOROWITZ JR; LYNCH G; GALL CM;
Indirizzi:
UNIV CALIF IRVINE,DEPT ANAT & NEUROBIOL IRVINE CA 92697 UNIV CALIF IRVINE,DEPT ANAT & NEUROBIOL IRVINE CA 92697 UNIV CALIF IRVINE,DEPT PSYCHOBIOL IRVINE CA 92697 UNIV CALIF IRVINE,BONNEY CTR NEUROBIOL LEARNING & MEMORY IRVINE CA 92697
Titolo Testata:
Journal of comparative neurology
fascicolo: 4, volume: 385, anno: 1997,
pagine: 491 - 502
SICI:
0021-9967(1997)385:4<491:SOARSM>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
SELECTIVE GLUTAMATE RECEPTORS; MESSENGER-RNAS; DIFFERENTIAL EXPRESSION; CA2+ PERMEABILITY; HIPPOCAMPAL-NEURONS; NEOCORTICAL NEURONS; KAINATE RECEPTORS; HABENULAR NUCLEI; CHANNELS; NMDA;
Keywords:
GLUTAMATE RECEPTOR; HIERARCHICAL CLUSTERING; IN SITU HYBRIDIZATION; HIPPOCAMPUS; NEOCORTEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
60
Recensione:
Indirizzi per estratti:
Citazione:
S.J. Gold et al., "STOICHIOMETRIES OF AMPA RECEPTOR SUBUNIT MESSENGER-RNAS IN RAT-BRAIN FALL INTO DISCRETE CATEGORIES", Journal of comparative neurology, 385(4), 1997, pp. 491-502

Abstract

In situ hybridization was used to estimate the relative concentrations of mRNAs encoding different subunits (GluR1-4) of alpha-amino 3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)-type glutamate receptors in rat brain and to test the hypothesis that within-region expression profiles reflect a limited number of recurring patterns. Fractional subunit mRNA concentrations were calculated for 33 brain regions, and cluster analysis methods were applied to test for statistically meaningful groupings in the data. Four relatively homogeneous classes were identified and designated as AMPA receptor (AR) categories, numbered according to dominant subunit mRNAs. The AR-1 class (47% GluR1 mRNA) was expressed by structures near the mesodiencephalic border, including basal ganglia-related areas. The AR-2 class (57% GluR2 mRNA) was expressed in cortex and tectum. The AR-1,2 class (31% GluR1, 45% GluR2) was foundin the largest number of regions, including such dissimilar cell fields as hippocampus and substantia nigra pars compacta. The AR-2,3 grouping (33% GluR2, 31% GluR3) was associated with the sensory relay and reticular thalamic nuclei. It is suggested that AR-1,2 and AR-2, the most closely related categories in clustering space, are largely telencephalic receptors with the former predominant in the subcortex and the latter in the cortex. The AR-2,3 class is associated with ascending sensory stations, whereas AR-1 appears to include several smaller categories expressed by specialized systems. If the balance of subunit mRNAsis reflected at the protein level, then the present data suggest thatforebrain AMPA-type glutamate receptors can be classified into a limited number of recurring types. (C) 1997 Wiley-Liss, Inc.

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Documento generato il 25/09/20 alle ore 16:11:14