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Titolo:
EXPERIMENTAL SYRINGOMYELIA - LATE ULTRASTRUCTURAL-CHANGES OF SPINAL-CORD TISSUE AND MAGNETIC-RESONANCE-IMAGING EVALUATION
Autore:
CHAKRABORTTY S; TAMAKI N; EHARA K; TAKAHASHI A; IDE C;
Indirizzi:
KOBE UNIV,SCH MED,DEPT NEUROSURG,CHUO KU,7-5-1 KUSUNOKI CHO KOBE HYOGO 650 JAPAN KOBE UNIV,SCH MED,DEPT NEUROSURG,CHUO KU KOBE HYOGO 650 JAPAN KYOTO UNIV,SCH MED,DEPT ANAT KYOTO 606 JAPAN
Titolo Testata:
Surgical neurology
fascicolo: 3, volume: 48, anno: 1997,
pagine: 246 - 254
SICI:
0090-3019(1997)48:3<246:ES-LUO>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL NERVOUS-SYSTEM; COMMUNICATING SYRINGOMYELIA; MULTIPLE-SCLEROSIS; FREEZING-INJURY; REMYELINATION; REGENERATION; EDEMA; RAT; HYDROCEPHALUS;
Keywords:
CHRONIC STAGE; EDEMA; EXPERIMENTAL SYRINGOMYELIA; RABBIT; SPINAL CORD; ULTRASTRUCTURAL CHANGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
S. Chakrabortty et al., "EXPERIMENTAL SYRINGOMYELIA - LATE ULTRASTRUCTURAL-CHANGES OF SPINAL-CORD TISSUE AND MAGNETIC-RESONANCE-IMAGING EVALUATION", Surgical neurology, 48(3), 1997, pp. 246-254

Abstract

BACKGROUND In human hydrosyringomyelia and in the late stage of experimental syringomyelia, the spinal cord tissue adjacent to the syrinx is exposed to a similar pathophysiologic condition. We investigated theultrastructural changes in the late stages of kaolin-induced syringomyelia, and in addition, we presented magnetic resonance imaging (MRT) findings of the cervicomedullary junction and syrinx, and the nature of edema in the spinal cord of this experimental model. METHODS Syringomyelia was induced in rabbits by intracisternal injection of kaolin. MRI was performed at 6 weeks, and 6 and 12 months following injection, and the animals were killed by transcardial perfusion of formaldehyde solution and examined by transmission electron microscopy. Evans blue was injected intravenously in six rabbits, 6 weeks and 12 months following kaolin injection and was examined by confocal laser scanning microscopy. RESULTS MRI showed that the syrinx communicated with the fourth ventricle in most animals. Demyelination of varying degrees and slight edematous change were seen in the perisyrinx white matter. No extravasation of Evans blue was seen by confocal microscopy. Abundant astrocytic proliferation with a large number of glial filaments was seen atthe margin of the syrinx and between the axons in the perisyringeal region. The perivascular space enlargement occurred in both the gray and white matter. The endothelial junctions appeared intact, Regenerating axons and remyelination by oligodendrocytes were seen occasionally. CONCLUSIONS The MRI confirmed the communication fourth ventricle and the syrinx. The changes were almost identical to those of the early stage syrinx, but the astrocytic proliferation was more severe, and the edema was less in the late stage. The perisyrinx edema appeared to be of the interstitial type, as in hydrocephalus. Axonal degeneration and demyelination continued with abortive attempt at regeneration and remyelination in the less edematous late stage, which might be the cellular basis for the persistence or worsening of clinical symptoms and signs in the chronic stage of syringomyelia even after surgical treatment. (C) 1997 by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 18:19:55