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Titolo:
[H-3] NEMONAPRIDE BINDING IN HUMAN CAUDATE AND PUTAMEN
Autore:
MARZELLA PL; COPOLOV D;
Indirizzi:
UNIV MELBOURNE,DEPT OTOLARYNGOL,ROYAL VICTORIAN EYE & EAR HOSP,32 GISBORNE ST MELBOURNE 3002 AUSTRALIA MENTAL HLTH RES INST,REBECCA L COOPER RES LABS PARKVILLE VIC AUSTRALIA NH & MRC SCHIZOPHRENIA RES UNIT PARKVILLE VIC AUSTRALIA
Titolo Testata:
Brain research bulletin
fascicolo: 2, volume: 44, anno: 1997,
pagine: 167 - 170
SICI:
0361-9230(1997)44:2<167:[NBIHC>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT-BRAIN; H-3 YM-09151-2; DOPAMINE-RECEPTORS; HIGH-AFFINITY; CLOZAPINE; RISPERIDONE; SCHIZOPHRENIA; ANTAGONIST; AUTORADIOGRAPHY; NEMONAPRIDE;
Keywords:
[H-3] NEMONAPRIDE BINDING; HUMAN CAUDATE; HUMAN PUTAMEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
P.L. Marzella e D. Copolov, "[H-3] NEMONAPRIDE BINDING IN HUMAN CAUDATE AND PUTAMEN", Brain research bulletin, 44(2), 1997, pp. 167-170

Abstract

The binding of [H-3]nemonapride to human postmortem caudate and putamen tissue was autoradiographically investigated using several antipsychotic drugs. Saturation experiments revealed a single population of binding sites (dissociation constant (K-D) 0.38 +/- 0.01 nM, and total binding capacity (B-MAX) 55 fmol/TE). Prototypic dopamine (DA) receptors antagonists displaced [H-3]nemonapride in a monophasic manner. The order of displacement potency was expected for DA D-2-like receptors: spiperone > (+)butaclamol greater than or equal to chlorpromazine > (-)sulpiride > ketanserin, Displacement with serotonergic antagonists suggests that in human caudate and putamen tissue [H-3]nemonapride may have a very low affinity serotonergic component. However, [H-3]nemonapride displays a high affinity and selectivity for DA D-2-like receptors and should make it a preferred compound for tritium-based autoradiography. (C) 1997 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 18:26:58