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Titolo:
ASYMMETRICAL EFFECTS OF THE UNILATERAL IMPLANT OF PILOCARPINE ON THE PREOPTIC-ANTERIOR HYPOTHALAMIC AREA ON SPONTANEOUS OVULATION OF THE ADULT-RAT
Autore:
LOPEZ E; CRUZ ME; DOMINGUEZ R;
Indirizzi:
UIBR FES ZARAGOZA,APARTADO POSTAL 9-020 MEXICO CITY 15000 DF MEXICO UNAM,UNIDAD INVEST BIOL REPROD,NEUROENDOCRINOL LAB,FAC ESTUDIOS SUPERZARAGOZA MEXICO CITY DF MEXICO
Titolo Testata:
Archives of medical research
fascicolo: 3, volume: 28, anno: 1997,
pagine: 343 - 348
SICI:
0188-4409(1997)28:3<343:AEOTUI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
ESTROUS-CYCLE; ATROPINE; RELEASE; NEURONS;
Keywords:
OVULATION; CHOLINERGIC SYSTEM; POA-AHA; ASYMMETRY; ESTRADIOL; POSITIVE FEEDBACK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
E. Lopez et al., "ASYMMETRICAL EFFECTS OF THE UNILATERAL IMPLANT OF PILOCARPINE ON THE PREOPTIC-ANTERIOR HYPOTHALAMIC AREA ON SPONTANEOUS OVULATION OF THE ADULT-RAT", Archives of medical research, 28(3), 1997, pp. 343-348

Abstract

The effects on ovulation at the next estrus after unilaterally implanting pilocarpine in the preoptic-anterior hypothalamic area (POA-AHA) of rats on each day of the estrous cycle were analyzed. Implantation on the left side of POA-ARA on the day of estrus blocked ovulation in all animals, whereas implantation on the right side did not (0/5 vs. 4/4, P<0.05). Implantation on diestrus 1 or 2 on either side of the POA-AHA blocked ovulation. Implantation on the right side of the POA-AHA at the day of proestrus blocked ovulation (1/6 animals ovulated), while10/12 with pilocarpine on the left side ovulated (P<0.05). The administration of 3.7 mu g of GnRH at 13:00 h on the expected day of proestrus induced ovulation in 36/42 treated animals. In rats with a pilocarpine implant, the injection of estradiol benzoate on diestrus 2 restored ovulation only in those animals with the pilocarpine implant placed in the left side of the POA-ARA, performed on the day of estrus. The results support the previous statements that in the adult rat POA-AHA, the cholinergic mechanism regulating preovulatory GnRH release, is lateralized. In addition, at the beginning of the estrous phase, the POA-AHA-cholinergic system needs to remain undisturbed for normal ovulation to take place at the next estrus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 02:06:49