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Titolo:
CHOLECYSTOKININ MODULATES MUCOSAL IMMUNOGLOBULIN-A FUNCTION
Autore:
ALVERDY J; STERN E; POTICHA S; BAUNOCH D; ADRIAN T;
Indirizzi:
UNIV CHICAGO,DEPT SURG & HEMATOPATHOL,5841 S MARYLAND AVE,MC 6090 CHICAGO IL 60637 CREIGHTON UNIV,DEPT BIOMED SCI OMAHA NE 68178
Titolo Testata:
Surgery
fascicolo: 2, volume: 122, anno: 1997,
pagine: 386 - 392
SICI:
0039-6060(1997)122:2<386:CMMIF>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT; INTESTINE; MONOCYTES; ADHERENCE; BOMBESIN; MOTILITY; BARRIER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
J. Alverdy et al., "CHOLECYSTOKININ MODULATES MUCOSAL IMMUNOGLOBULIN-A FUNCTION", Surgery, 122(2), 1997, pp. 386-392

Abstract

Background. We have established that mucosal immunoglobulin A (IgA) production is highly dependent on cholecystokinin release and is markedly suppressed by glucocorticoids. The purpose of the present study wasto examine the role of cholecystokinin on the functional responsiveness of the mucosal IgA system in glucocorticoid treated rats. Methods. A total of 24 Fischer rats were assigned to three groups of 8 animals each. Animals were injected with vehicle (CON), dexamethasone (DEX) (0.08 mg/150 g), or DEX (0.08 mg/150 gm) and ARL1294KF (500 ng twice daily), a novel and potent lon acting cholecystokinin agonist (DEX+CCK). Animals were treated for 48 hours and killed. Duodenum was harvested and the total mucosal concentration of cholecystokinin was measured by radioimmunoassay. Mucosal IgA was assayed by quantitation of immunoreactive cells in the ileum. Bacterial adherence was evaluated by quantitative culture of vigorously washed stripped cecal mucosa. Transepithelial electrical resistance, a measure of tight junction permeability, was assessed by mounting strips of adjacent cecal mucosa in Ussing chambers. Results. Glucocorticoid administration resulted in a statistically significant (P < 0.001) decrease in duodenal cholecystokinin, decreased IgA, and impaired mucosal immunity (increased bacterial adherenceand decreased tissue resistance). Cholecystokinin administration preserved mucosal immune function in DEX-treated rats. Conclusions. Cholecystokinin may play an important role in maintaining functional responsiveness of mucosal immunity during catabolic stress.

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Documento generato il 29/02/20 alle ore 13:53:21