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Titolo:
2 YEARS OF GROWTH-HORMONE (GH) TREATMENT INCREASE ISOMETRIC AND ISOKINETIC MUSCLE STRENGTH IN GH-DEFICIENT ADULTS
Autore:
JOHANNSSON G; GRIMBY G; SUNNERHAGEN KS; BENGTSSON BK;
Indirizzi:
SAHLGRENS UNIV HOSP,RES CTR ENDOCRINOL & METAB S-41345 GOTHENBURG SWEDEN SAHLGRENS UNIV HOSP,DEPT REHABIL MED S-41345 GOTHENBURG SWEDEN
Titolo Testata:
The Journal of clinical endocrinology and metabolism
fascicolo: 9, volume: 82, anno: 1997,
pagine: 2877 - 2884
SICI:
0021-972X(1997)82:9<2877:2YOG(T>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN SKELETAL-MUSCLE; CROSS-SECTIONAL AREA; QUADRICEPS MUSCLE; BODY-COMPOSITION; HYPOPITUITARY ADULTS; RESISTANCE EXERCISE; MEN; WOMEN; AGE; PERFORMANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
G. Johannsson et al., "2 YEARS OF GROWTH-HORMONE (GH) TREATMENT INCREASE ISOMETRIC AND ISOKINETIC MUSCLE STRENGTH IN GH-DEFICIENT ADULTS", The Journal of clinical endocrinology and metabolism, 82(9), 1997, pp. 2877-2884

Abstract

GH deficiency in adults is associated with reduced muscle mass and muscle strength. The objective of this trial was to follow the effect of2 yr of GH treatment in GH-deficient adults on muscle performance in relation to a reference population. Knee extensor and flexor strengthsfor isometric and isokinetic concentric muscle strength were measuredusing a Kin-Com dynamometer. Hand-grip strength was measured in both hands. The fatigue index was calculated as the percent reduction in peak torque at 50 repeated isokinetic knee extensions. Superimposed, single twitch electrical stimulation was performed. The GH-deficient subjects had lower isometric knee extensor, knee flexor, and hand-grip strength than the reference population. Two years of GH treatment increased and normalized the mean isometric knee extensor and flexor strengths. The concentric knee flexor and extensor strength at an angular velocity of pi rad/s increased, as did the concentric knee flexor strengthat an angular velocity of pi/3 rad/s. The increase in muscle strengthwas more-marked in younger patients and in patients with lower initial muscle strength than predicted. Quadriceps endurance decreased, whereas the effect of superimposing single twitches on isometric contraction and hand-grip strength was unaffected by the GH treatment. Two years of GH therapy in GH-deficient adults increased and normalized isokinetic and isometric muscle strength studied in proximal muscle groups. Hand-grip strength and the degree of lack of maximal motor unit activation on voluntary isometric knee extensor force did not change. The dynamic local muscle fatigue index decreased.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/05/20 alle ore 15:00:41