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Titolo:
COMPARATIVE-ANALYSIS OF SMOOTH-MUSCLE ISOACTIN GENE-EXPRESSION IN NORMAL AND NEOPLASTIC TISSUES
Autore:
BRITTINGHAM J; LIAW D; LIDDELL R; MCHUGH M; MCCUE P; MCHUGH KM;
Indirizzi:
THOMAS JEFFERSON UNIV,DEPT PATHOL ANAT & CELL BIOL,1020 LOCUST ST PHILADELPHIA PA 19107 THOMAS JEFFERSON UNIV,DEPT PATHOL ANAT & CELL BIOL PHILADELPHIA PA 19107 THOMAS JEFFERSON UNIV,JEFFERSON CANC INST PHILADELPHIA PA 19107 OUR LADY LOURDES HOSP,DEPT PATHOL CAMDEN NJ 00000
Titolo Testata:
Pathobiology
fascicolo: 3, volume: 65, anno: 1997,
pagine: 113 - 122
SICI:
1015-2008(1997)65:3<113:COSIGI>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERMEDIATE FILAMENT PROTEINS; ACTIN ISOFORMS; MONOCLONAL-ANTIBODY; STROMAL CELLS; GAMMA-ACTIN; TUMOR DIFFERENTIATION; HUMAN MYOMETRIUM; BETA-ACTIN; RAT; CONTRACTILE;
Keywords:
ACTIN; SMOOTH MUSCLE; LEIOMYOMAS; LEIOMYOSARCOMAS; TUMORIGENESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
J. Brittingham et al., "COMPARATIVE-ANALYSIS OF SMOOTH-MUSCLE ISOACTIN GENE-EXPRESSION IN NORMAL AND NEOPLASTIC TISSUES", Pathobiology, 65(3), 1997, pp. 113-122

Abstract

Monoclonal antibodies derived from the actin multigene family are routinely used as an adjunct to morphologic diagnoses of smooth muscle tumors. Northern blot analysis was performed on 60 surgical resections utilizing isoactin-specific cDNAs. A comparison of this analysis to immunohistochemical studies demonstrated that actin-specific monoclonal antibodies represent reliable markers of the smooth muscle lineage. Smooth muscle neoplasms showed a unique pattern of gamma-smooth muscle isoactin gene expression, providing a potentially valuable molecular adjunct to the morphologic diagnosis of uterine smooth muscle tumors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 05:28:51