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Titolo:
EFFECTS OF TYPICAL AND ATYPICAL ANTIPSYCHOTIC-DRUGS ON FREEZING BEHAVIOR INDUCED BY CONDITIONED FEAR
Autore:
INOUE T; TSUCHIYA K; KOYAMA T;
Indirizzi:
HOKKAIDO UNIV,SCH MED,DEPT PSYCHIAT,KITA KU,N 15, W 7 SAPPORO HOKKAIDO 060 JAPAN
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 2, volume: 55, anno: 1996,
pagine: 195 - 201
SICI:
0091-3057(1996)55:2<195:EOTAAA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOPAMINE-RECEPTORS; PREFRONTAL CORTEX; RAT-BRAIN; CLOZAPINE; STRESS; D-2; HALOPERIDOL; SEROTONIN; STRIATUM; INVIVO;
Keywords:
DOPAMINE; DOPAMINE D-4 RECEPTORS; CLOZAPINE; HALOPERIDOL; CONDITIONED FEAR STRESS; FREEZING BEHAVIOR; ATYPICAL ANTIPSYCHOTIC DRUG; SCHIZOPHRENIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
T. Inoue et al., "EFFECTS OF TYPICAL AND ATYPICAL ANTIPSYCHOTIC-DRUGS ON FREEZING BEHAVIOR INDUCED BY CONDITIONED FEAR", Pharmacology, biochemistry and behavior, 55(2), 1996, pp. 195-201

Abstract

A typical antipsychotic drugs (atypical APDs), such as clozapine, ORG5222, and olanzapine, have been suggested to possess anxiolytic activity in the conflict test and elevated plus-maze test, while several studies have suggested that typical APDs are not anxiolytic in several models of anxiety. We investigated the effects of typical and atypical APDs on the acquisition and expression of conditioned fear-induced freezing. Drugs were administered subcutaneously to male Sprague-Dawley rats 30 min before foot shock stress (the V160s schedule, 2.5 mA for 30 min). Twenty-four hours after foot shock, freezing behavior of rats was observed in the shock chamber without shocks. The atypical APD clozapine (0.3-10 mg/kg) dose-dependently inhibited the acquisition of conditioned freezing. Candidates for atypical APDs, ORG5222 (0.1-1 mg/kg),olanzapine (1-10 mg/kg), and raclopride (3-30 mg/kg), also reduced the acquisition of conditioned freezing in a dose-dependent manner. Typical APDs, haloperidol (3 mg/kg), spiperone (0.1-1 mg/kg) and nemonapride (1 mg/kg) had significant inhibitory effects on the acquisition of conditioned freezing, but their effects were reduced at higher doses. Chlorpromazine, a typical APD, showed about 50% inhibition of the acquisition of conditioned freezing at the dose of 10 mg/kg, but did not reveal significant inhibition at any of the doses (3-30 mg/kg). The ED(50)s (mg/kg) for inhibiting the acquisition of conditioned freezing significantly correlated with the K-i values for D-4 dopaminergic receptors, but not with the K-i values for other monoamine and acetylcholinereceptors. On the other hand, clozapine or haloperidol did not changethe expression of conditioned freezing. These results suggest that protective effects of clozapine and other antipsychotic drugs on the acquisition of conditioned freezing may be mediated by blockade of D-4 receptors. Copyright (C) 1996 Elsevier Science Inc.

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Documento generato il 28/09/20 alle ore 18:43:29