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Titolo:
THE PARASIGHT(TM)-F RAPID DIPSTICK ANTIGEN CAPTURE ASSAY FOR MONITORING PARASITE CLEARANCE AFTER DRUG-TREATMENT OF PLASMODIUM-FALCIPARUM MALARIA
Autore:
DIPERRI G; OLLIARO P; NARDI S; ALLEGRANZI B; DEGANELLO R; VENTO S; LANZAFAME M; CAZZADORI A; BONORA S; CONCIA E;
Indirizzi:
UNIV VERONA,IST IMMUNOL & MALATTIE INFET,OSPED CIVILE MAGGIORE I-37126 VERONA ITALY UNIV VERONA,INST IMMUNOL & INFECT DIS I-37100 VERONA ITALY UNDP,WORLD BANK,WHO,SPECIAL PROGRAMME RES & TRAINING TROP DIS GENEVA SWITZERLAND KIREMBA HOSP NGOZI BURUNDI
Titolo Testata:
Transactions of the Royal Society of Tropical Medicine and Hygiene
fascicolo: 4, volume: 91, anno: 1997,
pagine: 403 - 405
SICI:
0035-9203(1997)91:4<403:TPRDAC>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH PREVALENCE; DIAGNOSIS; MICROSCOPY; INFECTION;
Keywords:
MALARIA; PLASMODIUM FALCIPARUM; DIAGNOSIS; DIPSTICK ANTIGEN CAPTURE ASSAY; PARASIGHT(TM)-F TEST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
G. Diperri et al., "THE PARASIGHT(TM)-F RAPID DIPSTICK ANTIGEN CAPTURE ASSAY FOR MONITORING PARASITE CLEARANCE AFTER DRUG-TREATMENT OF PLASMODIUM-FALCIPARUM MALARIA", Transactions of the Royal Society of Tropical Medicine and Hygiene, 91(4), 1997, pp. 403-405

Abstract

Three methods for the detection of Plasmodium falciparum infection inperipheral blood were compared during antimalarial treatment and follow-up in 32 Burundian patients: dipstick antigen capture assay, standard (TBF) and prolonged thick blood film examination (PTBF) (3x5 min and 3x20 min examination respectively). Parasitaemia was determined daily by comparison with total white blood cell counts (determined by Coulter counter) until no parasite was detected on 2 consecutive days by PTBF Cumulatively, 231 observations were made with each assay: 64 were negative and 167 positive by PTBF (59 had parasite counts less than orequal to 100/mu L). Compared to PTBF, the sensitivities of TBF and the dipstick assay were 1.0 for parasite counts >100/mu L and 0.458 and 0.966 respectively for counts less than or equal to 100/mu L. Overall,the dipstick assay was significantly more sensitive (0.988 vs. 0.808;P<0.001) but less specific (P=0.013) than TBF. The dipstick assay is of potential use for monitoring response to drug treatment and for detecting low parasitaemias.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 03:08:39