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Titolo:
7-OH-DPAT HAS D-AMPHETAMINE-LIKE DISCRIMINATIVE STIMULUS PROPERTIES
Autore:
BEVINS RA; KLEBAUR JE; BARDO MT;
Indirizzi:
UNIV NEBRASKA,DEPT PSYCHOL LINCOLN NE 68588 UNIV KENTUCKY,DEPT PSYCHOL LEXINGTON KY 40506
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 2, volume: 58, anno: 1997,
pagine: 485 - 490
SICI:
0091-3057(1997)58:2<485:7HDDSP>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR AGONIST 7-OH-DPAT; D-3 DOPAMINE-RECEPTORS; RAT-BRAIN; SUBSTITUTED BENZAMIDE; PREFERRING COMPOUNDS; DRUG DISCRIMINATION; PLACE PREFERENCE; H-3 ETICLOPRIDE; COCAINE; IDENTIFICATION;
Keywords:
AMPHETAMINE; DOPAMINE; D2 AND D3 RECEPTORS; DRUG DISCRIMINATION; ETICLOPRIDE; OPERANT CONDITIONING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
R.A. Bevins et al., "7-OH-DPAT HAS D-AMPHETAMINE-LIKE DISCRIMINATIVE STIMULUS PROPERTIES", Pharmacology, biochemistry and behavior, 58(2), 1997, pp. 485-490

Abstract

BEVINS, R. A., J. E. KLEBAUR AND M. T. BARDO. 7-OH-DPAT has d-amphetaminelike discriminative stimulus properties. PHARMACOL BIOCHEM BEHAV 58(2) 485-490, 1997.--Rats were trained on a d-amphetamine (1 mg/kg) vs. saline discrimination task using food-maintained responding (fixed ratio = 25). In extinction tests, drug-appropriate responding decreasedas the dose of amphetamine was substituted for the training dose decreased. The dopamine D2/D3 receptor agonist (+/-)7-hydroxy-N,N-di-n-propyl-2-aminotetralin (7-OH-DPAT) substituted fully for the amphetamine discriminative stimulus at the higher doses examined (0.1, 0.3, 1.0 mg/kg). This substitution was accompanied by a substantial decrease in overall response rates. Eticlopride, a dopamine D2/D3 receptor antagonist, partially blocked 7-OH-DPAT substitution. Thus, at the higher doses, 7-OH-DPAT shared sufficient discriminative stimulus properties withthe amphetamine to prompt full substitution. Eticlopride antagonism suggests a role for the D2/D3 dopamine receptor in this substitution. (C) 1997 Elsevier Science inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 11:23:27