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Titolo:
EFFECTS OF THE COADMINISTRATION OF 5-HT1A RECEPTOR ANTAGONISTS WITH AN SSRI IN CONDITIONED FEAR STRESS-INDUCED FREEZING BEHAVIOR
Autore:
HASHIMOTO S; INOUE T; KOYAMA T;
Indirizzi:
HOKKAIDO UNIV,SCH MED,DEPT PSYCHIAT,KITA KU,N 15,W 7 SAPPORO HOKKAIDO060 JAPAN
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 2, volume: 58, anno: 1997,
pagine: 471 - 475
SICI:
0091-3057(1997)58:2<471:EOTCO5>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN REUPTAKE INHIBITORS; MICRODIALYSIS; RATS; INVIVO; BRAIN; 5-HYDROXYTRYPTAMINE; ANTIDEPRESSANTS; WAY100135; PINDOLOL; BLOCKADE;
Keywords:
CONDITIONED FEAR STRESS; FREEZING BEHAVIOR; SEROTONIN (5-HT); CITALOPRAM; NAN-190; (+)-WAY100135, 5-HT1A RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
S. Hashimoto et al., "EFFECTS OF THE COADMINISTRATION OF 5-HT1A RECEPTOR ANTAGONISTS WITH AN SSRI IN CONDITIONED FEAR STRESS-INDUCED FREEZING BEHAVIOR", Pharmacology, biochemistry and behavior, 58(2), 1997, pp. 471-475

Abstract

HASHIMOTO, S., T. INOUE AND T. KOYAMA. Effects of the co-administration of 5-HT1A receptor antagonists with an SSRI in conditioned fear stress-induced freezing behavior. PHARMACOL BIOCHEM BEHAV 58(2) 471-475, 1997.--The effects of the co-administration of the serotonin (5-HT) 1Areceptor antagonists NAN-190 or (+)-WAY100135 with a selective 5-HT reuptake inhibitor (SSRI) citalopram on conditioned fear stress (CFS)-induced freezing behavior, which is the animal model of anxiety, were examined. The inhibitory effects of co-administration of NAN 190 (0.1-10 mg/kg) with citalopram on CFS-induced freezing were potent; in particular, at 0.1 and 0.25 mg/kg, NAN-190 significantly enhanced the effect of citalopram alone. At 0.1 mg/kg, (+)-WAY100135 also markedly enhanced the inhibitory effect of citalopram on freezing behavior. These findings suggest that 5-HT1A receptor antagonist, particularly at low doses, enhances the antifreezing effect of citalopram by blocking the autoreceptor-mediated negative feedback mechanisms of the 5-HT neuron. These experimental results concur with clinical findings that 5-HT1A receptor antagonist pindolol potentiates the effect of 5-HT reuptake inhibitors. (C) 1997 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 17:39:24