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Titolo:
CENTRAL ADMINISTRATION OF IL-1 REDUCES ANXIETY AND INDUCES SICKNESS BEHAVIOR IN RATS
Autore:
MONTKOWSKI A; LANDGRAF R; YASSOURIDIS A; HOLSBOER F; SCHOBITZ B;
Indirizzi:
MAX PLANCK INST PSYCHIAT,DEPT NEUROENDOCRINOL,INST CLIN,KRAEPELINSTR 2 D-80804 MUNICH GERMANY
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 2, volume: 58, anno: 1997,
pagine: 329 - 336
SICI:
0091-3057(1997)58:2<329:CAOIRA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELEVATED PLUS-MAZE; TUMOR-NECROSIS-FACTOR; INTERLEUKIN-1; BRAIN; CYTOKINES; NEUROTRANSMISSION; MECHANISMS; INTERFERON; RECEPTORS; ENDOTOXIN;
Keywords:
ELEVATED PLUS-MAZE; INTERLEUKIN-1; ANXIETY; FEVER; SICKNESS BEHAVIOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
A. Montkowski et al., "CENTRAL ADMINISTRATION OF IL-1 REDUCES ANXIETY AND INDUCES SICKNESS BEHAVIOR IN RATS", Pharmacology, biochemistry and behavior, 58(2), 1997, pp. 329-336

Abstract

In the present study, we examined the effects of various doses of recombinant human interleukin-1 beta on anxiety-like behaviour, on body temperature, and on behavioural changes typical of sick animals. First,we assessed the behaviour of rats in the elevated plus-maze before and 20 min after intracerebroventricular injection of IL-1 at six doses ranging from 0.001 to 100 ng. After treatment with 0.1 and 100 ng IL-1, animals exhibited different anxiety levels. The dose effect on behavioural performance in the plus-maze appears to be nonlinear (parabolicfunction), with the highest effects near a 0.1-ng dose and the lowestnear doses of 0.0 and 100 ng. In a second set of experiments, we examined the effects of doses of 0.1 and 100 ng IL-1 (which had the most pronounced effects on performance in the plus-maze) on physical parameters over a 24-h period. Using radiotelemetry we measured body temperature, locomotor activity, food intake, and water consumption: a) in animals kept under basal resting conditions, and b) in animals exposed toa novel environment prior to administration of IL-1. Both doses evoked a fever response and reduced locomotor activity, but the increase inbody temperature did not correlate with the decrease in locomotor activity and both effects did not occur at the time of behavioural testing. Taken together, our data indicate that central administration of IL-1 has anxiolytic-like properties. (C) 1997 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 01:48:36