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Titolo:
ROLE OF BEHAVIORAL AND PHARMACOLOGICAL VARIABLES IN THE LOSS OF TOLERANCE TO AMPHETAMINE HYPOPHAGIA
Autore:
WOLGIN DL; HUGHES KH;
Indirizzi:
FLORIDA ATLANTIC UNIV,DEPT PSYCHOL BOCA RATON FL 33431
Titolo Testata:
Psychopharmacology
fascicolo: 4, volume: 132, anno: 1997,
pagine: 342 - 349
Fonte:
ISI
Lingua:
ENG
Soggetto:
TIME-DEPENDENT SENSITIZATION; UNDERSTANDING TOLERANCE; CONTINGENT TOLERANCE; CROSS-TOLERANCE; BODY-WEIGHT; STEREOTYPY; COCAINE; RATS; SUPPRESSION; ANOREXIA;
Keywords:
AMPHETAMINE; TOLERANCE; RETENTION OF TOLERANCE; INSTRUMENTAL LEARNING; DRUG WITHDRAWAL; STEREOTYPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
D.L. Wolgin e K.H. Hughes, "ROLE OF BEHAVIORAL AND PHARMACOLOGICAL VARIABLES IN THE LOSS OF TOLERANCE TO AMPHETAMINE HYPOPHAGIA", Psychopharmacology, 132(4), 1997, pp. 342-349

Abstract

Tolerance to amphetamine-induced hypophagia is lost when drug injections are withdrawn for 4 weeks while milk tests are continued (Wolgin and Hughes 1996). The purpose of this study was to determine whether the loss of tolerance is a function of drug withdrawal per se. Rats madetolerant to amphetamine (2 mg/kg, IP) were assigned to one of three groups. During the next 4 weeks (phase), one group continued to receiveamphetamine injections prior to daily milk tests (Before group), one group received drug injections after the milk tests (After group), andone group received injections of saline prior to the milk tests (Saline group). Dose-response tests revealed that the Before group retainedtolerance, whereas the After and Saline groups lost tolerance. When retested with chronic injections of amphetamine prior to milli, the After and Saline groups reacquired tolerance more rapidly, and to a greater extent, than non-tolerant controls. These results demonstrate that the loss of tolerance is not due to drug Withdrawal per se, but may bedue to the unlearning of behavioral strategies previously acquired under the drug.

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Documento generato il 27/01/21 alle ore 03:00:09