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Titolo:
CONTACT ACTIVATION OF PLASMATIC COAGULATION ON POLYMERIC MEMBRANES MEASURED BY THE ACTIVITY OF KALLIKREIN IN HEPARINIZED PLASMA
Autore:
GROTH T; SYNOWITZ J; MALSCH G; RICHAU K; ALBRECHT W; LANGE KP; PAUL D;
Indirizzi:
GKSS FORSCHUNGSZENTRUM GEESTHACHT GMBH,INST CHEM,DEPT MEMBRANE RES,KANTSTR 55 D-14513 TELTOW GERMANY HUMBOLDT UNIV BERLIN,SCH MED CHARITE,SCH DENT,DEPT PROSTHET D-10098 BERLIN GERMANY
Titolo Testata:
Journal of biomaterials science. Polymer ed.
fascicolo: 10, volume: 8, anno: 1997,
pagine: 797 - 807
SICI:
0920-5063(1997)8:10<797:CAOPCO>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANGIOTENSIN-CONVERTING-ENZYME; FACTOR-XII; ANAPHYLACTOID REACTIONS; HEMODIALYSIS MEMBRANES; PREKALLIKREIN; BIOMATERIALS; INHIBITORS; SURFACES; BIOCOMPATIBILITY; FRAGMENT;
Keywords:
MEMBRANES; POLYACRYLONITRILE; COPOLYMERS; CONTACT PHASE ACTIVATION; KALLIKREIN; HEPARIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
T. Groth et al., "CONTACT ACTIVATION OF PLASMATIC COAGULATION ON POLYMERIC MEMBRANES MEASURED BY THE ACTIVITY OF KALLIKREIN IN HEPARINIZED PLASMA", Journal of biomaterials science. Polymer ed., 8(10), 1997, pp. 797-807

Abstract

Kallikrein is involved in the generation of bradykinin during extracorporal circulation, that is believed to play an important role in cases of anaphylactic shock during hemodialysis. Therefore, a method for the assessment of kallikrein generation was developed, based on the chromogenic substrate S-2302. Comparison of kallikrein-like activity on glass using citrate or heparinized plasma demonstrated enhanced activity in the presence of heparin. The applicability of the assay, and the time course of kallikrein generation was demonstrated with glass and cuprophan. Membranes based on pure polyacrylonitrile, or its copolymersdiffering in their content of acrylic acid, 2-hydroxyethyl acrylate, and allylsulphonate were investigated with respect to kallikrein-like activity, and physicochemical surface properties. It was found that high content in 2-hydroxyethyl acrylate, and acrylic acid caused a substantial activation of the contact system while low content in allylsulphonate (less than 2 mol%) did not result in enhanced kallikrein-like activity. The activating materials were characterized to be highly wettable, and had the most negative zeta potentials.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/01/21 alle ore 22:05:36