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Titolo:
HEPATOTOXICITY OF FLUTAMIDE
Autore:
WIETZKE P; MUNKE H; HARTMANN H; RAMADORI G;
Indirizzi:
UNIV GOTTINGEN,ABT GASTROENTEROL & ENDOKRINOL,ZENTRUM INNERE MED,ROBERT KOCH STR 40 D-37075 GOTTINGEN GERMANY UNIV GOTTINGEN,ABT GASTROENTEROL & ENDOKRINOL,ZENTRUM INNERE MED D-37075 GOTTINGEN GERMANY
Titolo Testata:
Zeitschrift fur Gastroenterologie
fascicolo: 8, volume: 35, anno: 1997,
pagine: 631 - 635
SICI:
0044-2771(1997)35:8<631:HOF>2.0.ZU;2-2
Fonte:
ISI
Lingua:
GER
Soggetto:
PROSTATE-CANCER; LIVER TOXICITY; ANTIANDROGEN FLUTAMIDE; PLASMA-CONCENTRATIONS; GRAPEFRUIT JUICE; HEPATITIS; METABOLISM; CARCINOMA; SECONDARY; TRIAZOLAM;
Keywords:
FLUTAMIDE; HEPATOTOXICITY; TOXIC HEPATITIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
P. Wietzke et al., "HEPATOTOXICITY OF FLUTAMIDE", Zeitschrift fur Gastroenterologie, 35(8), 1997, pp. 631-635

Abstract

Flutamide is an antiandrogen and frequently used for the treatment ofmetastasized prostatic cancer. It is predominantly combined with an LH-RH-analog. Severe hepatotoxicity occurs in few patients but may be fatal. We report on two patients with metastatic prostate cancer who received flutamide and an LH-RH-analog. They showed variable degree of liver hepatotoxicity and recovered after with drawal of flutamide. The literature concerning tile metabolism of flutamide and the published cases of hepatotoxicity of this drug are reviewed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/02/20 alle ore 17:57:19