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Titolo:
THE EFFECT OF BASIC FIBROBLAST GROWTH-FACTOR ON CORONARY VASCULAR TONE IN EXPERIMENTAL HYPERCHOLESTEROLEMIA IN-VIVO AND IN-VITRO
Autore:
HASDAI D; MATHEW V; SCHWARTZ RS; HOLMES DR; LERMAN A;
Indirizzi:
MAYO CLIN & MAYO FDN,DIV CARDIOVASC DIS & INTERNAL MED,200 1ST ST SW ROCHESTER MN 55905 MAYO CLIN & MAYO FDN,DIV CARDIOVASC DIS & INTERNAL MED ROCHESTER MN 55905
Titolo Testata:
Coronary artery disease
fascicolo: 5, volume: 8, anno: 1997,
pagine: 299 - 304
SICI:
0954-6928(1997)8:5<299:TEOBFG>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; FLOW VELOCITY; NITRIC-OXIDE; ACIDIC FGF; ENDOTHELIUM; ARTERIES; EXPRESSION; ANGIOGENESIS; MYOCARDIUM; RECEPTOR;
Keywords:
BASIC FIBROBLAST GROWTH FACTOR; PIG; CORONARY ARTERY; CORONARY BLOOD FLOW; ENDOTHELIUM; HYPERCHOLESTEROLEMIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
D. Hasdai et al., "THE EFFECT OF BASIC FIBROBLAST GROWTH-FACTOR ON CORONARY VASCULAR TONE IN EXPERIMENTAL HYPERCHOLESTEROLEMIA IN-VIVO AND IN-VITRO", Coronary artery disease, 8(5), 1997, pp. 299-304

Abstract

Objective To determine whether bFGF causes coronary vasoconstriction in experimental hypercholesterolemia in association with endothelial dysfunction. Methods We infused 0.02 mu g/kg per min bFGF into the leftanterior descending artery of anesthetized pigs (n=5) before and after 10 weeks of a high-cholesterol diet. The coronary artery diameter (CAD) was measured by quantitative angiography and the coronary blood flow (CBF) was calculated using coronary-flow Doppler measurements. In additional in-vitro studies, epicardial arteries from normal and hypercholesterolemic pigs were exposed to cumulative concentrations of bradykinin (10(-11)-10(-6) mol/l) after precontraction with 10(-6) mol/l endothelin-l. Cumulative concentrations of bFGF (10(-13)-10(-8) mol/l) were added to other vessels with and without prior contraction with 10(-6) mol/l PGF(2 alpha). Similar in-vitro studies were performed using rings from which the endothelium had been removed. Results In vivo, intracoronary administration of bFGF increased the CBF by 33 +/- 33% andthe CAD by 12 +/- 5% at baseline, but reduced the CBF by 45 +/- 8% and the CAD by 14 +/- 6% after 10 weeks of a high-cholesterol diet. In vitro, the endothelium-dependent vasorelaxation in response to bradykinin was attenuated significantly in coronary arteries from hypercholesterolemic pigs (P<0.05). Cumulative concentrations of bFGF exerted no effect on the coronary epicardial tone both in normal (with and withoutendothelium) and in hypercholesterolemic pigs. Conclusions Acute administration of intracoronary bFGF caused coronary vasodilatation under steady-state conditions and vasoconstriction under diet-induced hypercholesterolemia. In vitro, bFGF did not affect the coronary epicardial tone. These findings suggest that the coronary vasoactive properties of bFGF may be exerted indirectly and are affected by the functional integrity of the endothelium. (C) Rapid Science Publishers ISSN 0954-6928.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 22:32:43