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Titolo:
EFFECTS OF THE IMMUNOSUPPRESSANT CYCLOSPORINE-A ON NEUROTRANSMITTER RELEASE FROM PERIPHERAL NONADRENERGIC, NONCHOLINERGIC NERVES
Autore:
KAGEYAMA M; FUJITA H; NAKATA K; SHIRASAWA E; KANAI A;
Indirizzi:
SANTEN PHARMACEUT CO LTD,OPHTHALM RES DIV,8916-16 TAKAYAMA CHO NARA 63001 JAPAN JUNTENDO UNIV,SCH MED,DEPT OPHTHALMOL,BUNKYO KU TOKYO 113 JAPAN
Titolo Testata:
Naunyn-Schmiedeberg's archives of pharmacology
fascicolo: 3, volume: 356, anno: 1997,
pagine: 398 - 403
SICI:
0028-1298(1997)356:3<398:EOTICO>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
IRIS SPHINCTER MUSCLE; SUBSTANCE-P; RABBIT IRIS; CA2+ CHANNELS; RATS; ACETYLCHOLINE; CYCLOPHILIN; STIMULATION; CALCINEURIN; INHIBITION;
Keywords:
CYCLOSPORINE A; SUBSTANCE P; NICARDIPINE; VOLTAGE-DEPENDENT CA2+ CHANNELS; NEUROTRANSMITTER RELEASE; SMOOTH MUSCLE CONTRACTION; TACHYKININERGIC NERVES; RABBIT IRIS SPHINCTER MUSCLE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
M. Kageyama et al., "EFFECTS OF THE IMMUNOSUPPRESSANT CYCLOSPORINE-A ON NEUROTRANSMITTER RELEASE FROM PERIPHERAL NONADRENERGIC, NONCHOLINERGIC NERVES", Naunyn-Schmiedeberg's archives of pharmacology, 356(3), 1997, pp. 398-403

Abstract

This study was undertaken to determine the effect of the immunosuppressant cyclosporin A on neurotransmitter release from non-adrenergic, non-cholinergic nerves (tachykininergic nerves) in the rabbit iris sphincter muscle. Cumulative application of cyclosporin A (0.1 to 10 mu M)caused a slow onset of contraction in a concentration-dependent manner. Both FK888 (1 mu M) and capsaicin (10 mu M), a substance P receptorantagonist and a substance P-depleting agent, respectively, inhibitedthe contractile effect of cyclosporin A, whereas atropine (1 mu M) had no effect. Both cyclosporin A and capsaicin (10 mu M) stimulated therelease of substance P-like immunoreactivity in the iris. Neither thesodium channel blocker tetrodotoxin (1 mu M), the N-type voltage-dependent Ca2+ channel blocker omega-conotoxin GVIA (1 mu M) nor the P-type channel blocker omega-agatoxin IVA (0.2 mu M) affected cyclosporin A(1 mu M)-induced contraction. In contrast, the L-type Ca2+ channel blocker nicardipine (10 mu M) inhibited this contractile effect. These results suggest that cyclosporin A stimulates substance P-like tachykinin release by activating L-type voltage-dependent Ca2+ channels, resulting in contraction of the rabbit iris sphincter muscle.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:54:52