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Titolo:
THE EFFECTS OF SEVOFLURANE ON RECOVERY OF BRAIN ENERGY-METABOLISM AFTER CEREBRAL-ISCHEMIA IN THE RAT - A COMPARISON WITH ISOFLURANE AND HALOTHANE
Autore:
NAKAJIMA Y; MORIWAKI G; IKEDA K; FUJISE Y;
Indirizzi:
3600 HANDA CHO HAMAMATSU SHIZUOKA 43131 JAPAN HAMAMATSU UNIV,SCH MED,DEPT ANESTHESIOL & INTENS CARE HAMAMATSU SHIZUOKA 43131 JAPAN HAMAMATSU UNIV,SCH MED,DEPT CHEM HAMAMATSU SHIZUOKA 43131 JAPAN
Titolo Testata:
Anesthesia and analgesia
fascicolo: 3, volume: 85, anno: 1997,
pagine: 593 - 599
SICI:
0003-2999(1997)85:3<593:TEOSOR>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRACRANIAL-PRESSURE; NMR-SPECTROSCOPY; INTRACELLULAR PH; CREATINE-KINASE; BLOOD-FLOW; ENFLURANE; ANESTHESIA; RABBIT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
Y. Nakajima et al., "THE EFFECTS OF SEVOFLURANE ON RECOVERY OF BRAIN ENERGY-METABOLISM AFTER CEREBRAL-ISCHEMIA IN THE RAT - A COMPARISON WITH ISOFLURANE AND HALOTHANE", Anesthesia and analgesia, 85(3), 1997, pp. 593-599

Abstract

Isoflurane is an appropriate anesthetic for neuroanesthesia. We evaluated whether the effect of sevoflurane is similar to that of isoflurane or halothane on brain energy metabolism after cerebral ischemia followed by reperfusion using P-31-magnetic resonance spectroscopy. Wistarrats (n = 21) were divided into three groups: isoflurane-, sevoflurane-, or halothane-treated. After anesthesia induction;and surgical preparation, each anesthetic concentration was adjusted to 1 minimum alveolar anesthetic concentration. Cerebral ischemia was induced with bilateral carotid occlusion and reduction of mean arterial blood pressure to 30-40 mm Hg by blood withdrawal. Magnetic resonance measurements were performed during ischemia and for 120 min of reperfusion. Intracellular pH in the isoflurane-treated, sevoflurane-treated, and halothane-treated groups decreased to 6.180 +/- 0.149, 6.125 +/- 0.134, and 6.027+/- 0.157, respectively, at the end of ischemia. There were no differences in the change of phosphorous compounds and intracellular pH between the isoflurane-treated and the sevoflurane-treated groups during ischemia and reperfusion. However, in the halothane-treated group, we observed a significant delay in the recovery of adenosine triphosphate and intracellular pH (0.038 +/- 0.013 pH unit/min compared with 0.064 /- 0.011 in the isoflurane-treated group and 0.058 +/- 0.008 in the sevoflurane-treated group) until 24 min of reperfusion (P < 0.05). We conclude that sevoflurane has effects similar to isoflurane on brain energy metabolism during and after cerebral ischemia. Implications: It is important to know whether anesthetics adversely effect brain metabolism during ischemia and reperfusion. A new anesthetic, sevoflurane, affected the brain in a manner similar to isoflurane, which has been used for many years as an anesthetic.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 09:27:06