Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
PRENATAL CORTICOSTERONE TREATMENT INDUCES LONG-TERM CHANGES IN SPONTANEOUS AND APOMORPHINE-MEDIATED MOTOR-ACTIVITY IN MALE AND FEMALE RATS
Autore:
DIAZ R; FUXE K; OGREN SO;
Indirizzi:
KAROLINSKA INST,DEPT NEUROSCI,DIV CELLULAR & NEUROCHEM S-17177 STOCKHOLM SWEDEN
Titolo Testata:
Neuroscience
fascicolo: 1, volume: 81, anno: 1997,
pagine: 129 - 140
SICI:
0306-4522(1997)81:1<129:PCTILC>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED LOCOMOTOR-ACTIVITY; ADRENAL ACTIVITY AFFECT; NUCLEUS-ACCUMBENS; SEX-DIFFERENCES; MONOAMINERGIC NEURONS; PLASMA-CORTICOSTERONE; DOPAMINE METABOLISM; CORPUS STRIATUM; D-AMPHETAMINE; ADULT-RATS;
Keywords:
GLUCOCORTICOIDS; DOPAMINE; DEVELOPMENT; MOTOR BEHAVIOR; APOMORPHINE; SEX DIFFERENCES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
53
Recensione:
Indirizzi per estratti:
Citazione:
R. Diaz et al., "PRENATAL CORTICOSTERONE TREATMENT INDUCES LONG-TERM CHANGES IN SPONTANEOUS AND APOMORPHINE-MEDIATED MOTOR-ACTIVITY IN MALE AND FEMALE RATS", Neuroscience, 81(1), 1997, pp. 129-140

Abstract

The potential influence of glucocorticoids on fetal brain developmentwas investigated after corticosterone administration via pellets to pregnant rats during the last trimester of gestation. We examined both spontaneous motor activity and dopamine-mediated motor responses to apomorphine, a D-1, D-2 and D-3 receptor agonist, given al a postsynaptic dose (1 mg/kg, s.c.) to both prepubertal and adult male and female offspring. Prenatal corticosterone was found to produce the following alterations in the offspring. (1) Prepubertal stage: Male offspring: a statistically significant (P<0.05) increase was observed in spontaneous rearing, motility and locomotion (activity measured during the first30 min) without changes in apomorphine-induced motor responses. Female offspring: a reduction (P<0.05) only in spontaneous rearing activitywas observed during the exploratory phase (activity measured during the first 10 min) without significant changes in apomorphine-induced motor responses. (2) Adult stage: Male offspring: the exploratory activity to the novel environment was increased (P<0.05) without significantchanges in apomorphine-induced motor activity. Female offspring: an increase (P<0.05) in spontaneous locomotion was observed during the first 30 min of testing without significant changes in exploratory activity to the novel environment. However, the apomorphine-induced motilityand locomotion were reduced (P<0.05) during the first 30 min. These observations indicate that prenatal corticosterone induces both short-term and long-term changes in spontaneous motor activity as well as long-lasting alterations in dopamine receptor response in the motor network mechanisms controlled by DA receptors. These changes are in part age and sex-dependent. The possible relationship between prenatal programming of the mesolimbic and nigrostriatal dopaminergic pathways by corticosterone and the observed changes in motor function is discussed. (C) 1997 IBRO. Published by Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 22:06:19