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Titolo:
MODULATION OF CHOLINERGIC NUCLEUS BASALIS NEURONS BY ACETYLCHOLINE AND N-METHYL-D-ASPARTATE
Autore:
KHATEB A; FORT P; WILLIAMS S; SERAFIN M; JONES BE; MUHLETHALER M;
Indirizzi:
CTR MED UNIV GENEVA,DEPT PHYSIOL,1 RUE MICHEL SERVET CH-1211 GENEVA 4SWITZERLAND CTR MED UNIV GENEVA,DEPT PHYSIOL CH-1211 GENEVA 4 SWITZERLAND UNIV LYON 1,FAC MED,DEPT EXPT MED,CNRS,URA 1195,INSERM,U52 F-69373 LYON FRANCE MCGILL UNIV,MONTREAL NEUROL INST,DEPT NEUROL & NEUROSURG MONTREAL PQ H3A 2B4 CANADA
Titolo Testata:
Neuroscience
fascicolo: 1, volume: 81, anno: 1997,
pagine: 47 - 55
SICI:
0306-4522(1997)81:1<47:MOCNBN>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
LATERAL GENICULATE-NUCLEUS; CENTRAL-NERVOUS-SYSTEM; BRAIN-STEM AFFERENTS; GUINEA-PIG BRAIN; IN-VITRO; NORADRENERGIC MODULATION; MUSCARINIC RECEPTOR; REM-SLEEP; ELECTROENCEPHALOGRAM DESYNCHRONIZATION; PONTOMESENCEPHALIC TEGMENTUM;
Keywords:
AROUSAL; BASAL FOREBRAIN; GUINEA-PIG; SLEEP; SLICES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
68
Recensione:
Indirizzi per estratti:
Citazione:
A. Khateb et al., "MODULATION OF CHOLINERGIC NUCLEUS BASALIS NEURONS BY ACETYLCHOLINE AND N-METHYL-D-ASPARTATE", Neuroscience, 81(1), 1997, pp. 47-55

Abstract

Known to exert an important modulatory influence on the cerebral cortex, the cholinergic neurons of the basal forebrain are modulated in turn by neurotransmitters which may include acetylcholine released from processes of brainstem or forebrain neurons. In the present study, we examined the effect of carbachol, a non-specific cholinergic agonist, either alone or in the presence of N-methyl-D-aspartate upon electrophysiologically identified cholinergic basalis neurons in guinea-pig basal forebrain slices. Carbachol produced a direct postsynaptic hyperpolarization, accompanied by a decrease in membrane resistance. Muscarinecould mimic this hyperpolarizing effect, whereas nicotine produced a direct postsynaptic membrane depolarization. The interaction of carbachol with N-methyl-D-aspartate was subsequently tested since, in a prior study, N-methyl-D-aspartate was shown to induce rhythmic bursting incholinergic cells when they were hyperpolarized by continuous injection of outward current. Applied simultaneously with iv-methyl-D-aspartate in the absence of current injection, carbachol was also found to promote rhythmic bursting in half of the cells rested. Since the bursts under these conditions were markedly longer in duration than those observed in the presence of N-methyl-D-aspartate alone, it was hypothesized that carbachol might have another action, in addition to the membrane hyperpolarization. Using dissociated cells, it was found that briefapplications of carbachol could indeed diminish the slow afterhyperpolarizations that follow single spikes, short bursts or long trains of action potentials in cholinergic basalis neurons. These results indicate that, through its dual ability to hyperpolarize cholinergic neuronsand to reduce their afterhyperpolarizations, acetylcholine can promote the occurrence of rhythmic bursting in the presence of N-methyl-D-aspartate. Accordingly, whether derived from brainstem or local sources,acetylcholine may facilitate rhythmic discharge in cholinergic basalis neurons which could in turn impose a rhythmic modulation upon cortical activity during particular states across the sleep-waking cycle. (C) 1997 IBRO. Published by Elsevier Science Ltd.

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Documento generato il 07/07/20 alle ore 12:34:54