Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
GENETIC-HETEROGENEITY OF MIGRAINE WITH AND WITHOUT AURA IN DANES CANNOT BE EXPLAINED BY MUTATION IN MTDNA NUCLEOTIDE PAIR-11084
Autore:
RUSSELL MB; DIAMANT M; NORBY S;
Indirizzi:
UNIV COPENHAGEN,GLOSTRUP HOSP,DEPT NEUROL DK-2600 GLOSTRUP DENMARK RIGSHOSP,LAB MED IMMUNOL,INST INFLAMMAT RES,RHIMA CTR DK-2100 COPENHAGEN DENMARK UNIV COPENHAGEN,INST FORENS MED DK-2100 COPENHAGEN DENMARK
Titolo Testata:
Acta neurologica Scandinavica
fascicolo: 3, volume: 96, anno: 1997,
pagine: 171 - 173
SICI:
0001-6314(1997)96:3<171:GOMWAW>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE SPECTROSCOPY; FAMILIAL HEMIPLEGIC MIGRAINE; BRAIN ENERGY-METABOLISM; MITOCHONDRIAL CYTOPATHIES; LOCUS;
Keywords:
MIGRAINE; GENETICS; MITOCHONDRIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
M.B. Russell et al., "GENETIC-HETEROGENEITY OF MIGRAINE WITH AND WITHOUT AURA IN DANES CANNOT BE EXPLAINED BY MUTATION IN MTDNA NUCLEOTIDE PAIR-11084", Acta neurologica Scandinavica, 96(3), 1997, pp. 171-173

Abstract

Introduction - Migraine is a genetic heterogeneous disorder. The 11084 A to G base substitution is in the gene for the ND4 subunit of the respiratory complex I, and leads to a Thr to Ala amino acid replacement. This mutation had been found in 25% of Japanese migraineurs, while tension-type headache sufferers and non-migraineurs did not have it. Material and methods - We investigated the importance of this mutation in Danish migraineurs without aura, migraineurs with aura and non-migraineurs from the general population. Results - We did not detect this mutation in Danes. Conclusion - Our result excludes a significant role of this mutation in the etiology of migraine in Denmark, and its absence in non-migraineurs supports that this mutation is rare in non-Japanese populations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 10:33:41