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Titolo:
OVEREXPRESSION OF THE MTA1 GENE IN GASTROINTESTINAL CARCINOMAS - CORRELATION WITH INVASION AND METASTASIS
Autore:
TOH Y; OKI E; ODA S; TOKUNAGA E; OHNO S; MAEHARA Y; NICOLSON GL; SUGIMACHI K;
Indirizzi:
KYUSHU UNIV,MED INST BIOREGULAT,DEPT SURG,4546 TSURUMIHARA BEPPU OITA874 JAPAN KYUSHU UNIV,FAC MED,DEPT SURG 2 FUKUOKA 812 JAPAN KYUSHU UNIV HOSP,CTR CANC FUKUOKA 812 JAPAN INST MOL MED IRVINE CA 00000
Titolo Testata:
International journal of cancer
fascicolo: 4, volume: 74, anno: 1997,
pagine: 459 - 463
SICI:
0020-7136(1997)74:4<459:OOTMGI>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE CHAIN-REACTION; MAMMARY ADENOCARCINOMA; CANCER METASTASIS; CELL-LINES; EXPRESSION; PROTEIN; QUANTITATION; DOMAINS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
Y. Toh et al., "OVEREXPRESSION OF THE MTA1 GENE IN GASTROINTESTINAL CARCINOMAS - CORRELATION WITH INVASION AND METASTASIS", International journal of cancer, 74(4), 1997, pp. 459-463

Abstract

The mtal gene is a recently identified novel candidate metastasis associated gene. The deduced amino acid sequence contains an src homology-3 domain binding motif, a zinc finger motif and possible phosphorylation sites, suggesting that this gene is involved in signal transduction or regulation of gene expression. The purpose of our study was to examine the mRNA expression levels of the MTAI, the human homologue of the rat mtal gene in colorectal and gastric carcinomas and thus to evaluate the relevance of the expression of this gene to human carcinoma progression. The expression of MTAI mRNA in 36 colorectal and 34 gastric carcinoma samples was compared with that in corresponding normal mucosa tissues by semi-quantitative reverse-transcription polymerase chain reaction (RT-PCR) and the results were compared with clinico-pathologic data. A relative overexpression of MTAI mRNA (tumor/normal ratio greater than or equal to 2) was observed in 14 of 36 (38.9%) colorectalcarcinomas and 13 of 34 (38.2%) gastric carcinomas, Clinico-pathologic correlations demonstrated that in colorectal carcinomas, tumors overexpressing MTAI mRNA exhibited a significantly deeper wall invasion and a higher rate of metastasis to lymph nodes, and tended to be at an advanced Dukes' stage with frequent lymphatic involvement, In gastric carcinomas, the tumors overexpressing MTAI mRNA showed significantly higher rates of serosal invasion and lymph node metastasis and tended tohave a higher rate of vascular involvement. Our data suggest that overexpression of the MTAI gene correlates with tumor invasion and the presence of metastases and that a high expression of MTAI mRNA may be a potential indicator for assessing the malignant potential of colorectal and gastric carcinomas, (C) 1997 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 01:31:59