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Titolo:
VASCULAR ENDOTHELIAL GROWTH-FACTOR (VEGF) IN HUMAN BREAST-CANCER - CORRELATION WITH DISEASE-FREE SURVIVAL
Autore:
OBERMAIR A; KUCERA E; MAYERHOFER K; SPEISER P; SEIFERT M; CZERWENKA K; KAIDER A; LEODOLTER S; KAINZ C; ZEILLINGER R;
Indirizzi:
UNIV HOSP VIENNA,DEPT OBSTET & GYNECOL,WAHRINGER GURTEL 18-20 A-1090 VIENNA AUSTRIA UNIV HOSP VIENNA,DEPT SENOL A-1090 VIENNA AUSTRIA UNIV HOSP VIENNA,DEPT CLIN PATHOL,GYNECOPATHOL UNIT A-1090 VIENNA AUSTRIA UNIV HOSP VIENNA,DEPT MED COMP SCI CLIN BIOMETR A-1090 VIENNA AUSTRIA
Titolo Testata:
International journal of cancer
fascicolo: 4, volume: 74, anno: 1997,
pagine: 455 - 458
SICI:
0020-7136(1997)74:4<455:VEG(IH>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR ANGIOGENESIS; PROGNOSTIC INDICATOR; MICROVESSEL DENSITY; PERMEABILITY FACTOR; VESSEL INVASION; CARCINOMA; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
A. Obermair et al., "VASCULAR ENDOTHELIAL GROWTH-FACTOR (VEGF) IN HUMAN BREAST-CANCER - CORRELATION WITH DISEASE-FREE SURVIVAL", International journal of cancer, 74(4), 1997, pp. 455-458

Abstract

Studies have shown that microvessel density influences breast-cancer prognosis, Since tumor angiogenesis is considered to be substantially affected by the excretion of vascular endothelial growth factor (VEGF)from tumor cells, we examined whether VEGF concentration is differentin malignant and in non malignant breast tissue, It was also of interest to discover whether intratumoral VEGF concentration influences disease-free survival (DFS) of breast-cancer patients. Analysis is based on 120 tissue specimens taken from breast fibromas (n = 23), normal epithelial breast tissue adjacent to fibromas (n = 8) and invasive breast cancer (n = 89), VEGF concentration was quantified by using an immunoassay. Microvessel density was determined by immunostaining for factor-VIII-related antigen. Median VEGF concentration is given in pg/mg protein (25%-quantile-75%-quantile) and it was 0 (0-1.8) in normal breast tissue, 9.8 (0.52-43.0) in fibromas and 130.4 (50.8-362.2) in invasive carcinomas, A univariate Cox model revealed that node status, tumorsize, estrogen-receptor concentration, histological grading and microvessel density were prognostic factors for disease-free survival in breast cancer. We found a significant correlation between VEGF concentration and microvessel count, but VEGF concentration did not significantly influence disease-free survival. Although VEGF protein was found ata significantly higher concentration in malignant than in nonmalignant tissue, determination of intratumoral VEGF protein by an enzyme immunoassay was not prognostically relevant in our patient population, (C)1997 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 10:08:33