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Titolo:
LYMPHOPROLIFERATIVE RESPONSES TO HUMAN-PAPILLOMAVIRUS (HPV) TYPE-16 PROTEINS E6 AND E7 - OUTCOME OF HPV INFECTION AND ASSOCIATED NEOPLASIA
Autore:
KADISH AS; HO GYF; BURK RD; WANG YX; ROMNEY SL; LEDWIDGE R; ANGELETTI RH;
Indirizzi:
ALBERT EINSTEIN COLL MED,DEPT PATHOL,1300 MORRIS PK AVE BRONX NY 10461 ALBERT EINSTEIN COLL MED,DEPT EPIDEMIOL & SOCIAL MED BRONX NY 10467 ALBERT EINSTEIN COLL MED,DEPT PEDIAT BRONX NY 10467 ALBERT EINSTEIN COLL MED,DEPT MICROBIOL & IMMUNOL BRONX NY 10467 ALBERT EINSTEIN COLL MED,DEPT PATHOL BRONX NY 10467 ALBERT EINSTEIN COLL MED,DEPT OBSTET & GYNECOL BRONX NY 10467 ALBERT EINSTEIN COLL MED,DEPT DEV & MOL BIOL BRONX NY 10467
Titolo Testata:
Journal of the National Cancer Institute
fascicolo: 17, volume: 89, anno: 1997,
pagine: 1285 - 1293
Fonte:
ISI
Lingua:
ENG
Soggetto:
CERVICAL INTRAEPITHELIAL NEOPLASIA; LONGITUDINAL DATA-ANALYSIS; CYTOTOXIC LYMPHOCYTES-T; RISK-FACTORS; CELL RESPONSES; PEPTIDES; WOMEN; ANTIBODIES; EPITOPES; CANCER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
A.S. Kadish et al., "LYMPHOPROLIFERATIVE RESPONSES TO HUMAN-PAPILLOMAVIRUS (HPV) TYPE-16 PROTEINS E6 AND E7 - OUTCOME OF HPV INFECTION AND ASSOCIATED NEOPLASIA", Journal of the National Cancer Institute, 89(17), 1997, pp. 1285-1293

Abstract

Background: Infection with human papillomavirus (HPV) type 16 (HPV16)is a major cause of high-grade cervical intraepithelial neoplasia (GIN). Experiments were planned to evaluate the role of cell-mediated immunity (e.g., lymphocyte proliferation) against HPV in the natural history of HPV-associated neoplasia and to identify antigenic sequences ofthe HPV16 proteins E6 and E7 against which an immune response may confer protection. Methods: Forty-nine women with abnormal cervical cytology and biopsy-confirmed CIN were followed through one or more clinic visits, Lymphoproliferative responses of peripheral blood mononuclear cells to HPV16 E6 and E7 peptides were assessed in long-term (3-week) cultures, HPV DNA was detected in cervicovaginal lavage by means of polymerase chain reaction and Southern blotting. Disease status was determined by cervical cytologic examination and colposcopy, Reported P values are two-sided, Results: Subjects with positive lymphoproliferative responses to E6 and/or E7 peptides were more likely to be HPV negative at the same clinic visit than were nonresponders (P=.039). Subjectswho were negative for HPV and those with a low viral load were more likely to be responders than were those with a high viral load (P for trend=.037). Responses to N-terminal E6 peptide 369 were associated with absence of HPV infection at the same clinic visit (P=.015). Subjectswith positive responses to E6 or E7 peptides at one clinic visit were4.4 times more likely to be HPV negative at the next visit than were nonresponders (P=.142). Responses to E6 peptide 369 and/or E7 C-terminal peptide 109 were associated with an absence of HPV infection (P=.02for both) and an absence of CIN (P=.04 and .02, respectively) at the next visit, Conclusions: Lymphoproliferative responses to specific HPV16 E6 and E7 peptides appear to be associated with the clearance of HPV infection and the regression of GIN.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/21 alle ore 06:32:44