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Titolo:
TOBACCO, ALCOHOL, AND SOCIOECONOMIC-STATUS AND ADENOCARCINOMAS OF THEESOPHAGUS AND GASTRIC CARDIA
Autore:
GAMMON MD; SCHOENBERG JB; AHSAN H; RISCH HA; VAUGHAN TL; CHOW WH; ROTTERDAM H; WEST AB; DUBROW R; STANFORD JL; MAYNE ST; FARROW DC; NIWA S; BLOT WJ; FRAUMENI JF;
Indirizzi:
622 W 168TH ST,PH18-107 NEW YORK NY 10032 COLUMBIA SCH PUBL HLTH,DIV EPIDEMIOL NEW YORK NY 00000 NEW JERSEY DEPT HLTH & SENIOR SERV,APPL CANC EPIDEMIOL PROGRAM TRENTON NJ 00000 YALE UNIV,SCH MED,DEPT EPIDEMIOL & PUBL HLTH NEW HAVEN CT 06510 YALE UNIV,SCH MED,DEPT PATHOL NEW HAVEN CT 06510 FRED HUTCHINSON CANC RES CTR,PROGRAM EPIDEMIOL SEATTLE WA 98104 UNIV WASHINGTON,SCH PUBL HLTH,DEPT EPIDEMIOL SEATTLE WA 98195 NCI,DIV CANC EPIDEMIOL & GENET BETHESDA MD 00000 COLUMBIA UNIV,COLL PHYS & SURG,DEPT PATHOL NEW YORK NY 00000 WESTAT CORP ROCKVILLE MD 00000 INT EPIDEMIOL INST ROCKVILLE MD 00000
Titolo Testata:
Journal of the National Cancer Institute
fascicolo: 17, volume: 89, anno: 1997,
pagine: 1277 - 1284
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDICAL CONDITIONS; CIGARETTE-SMOKING; HISTOLOGIC TYPE; UNITED-STATES; LIFE-STYLE; CANCER; RISK; CONSUMPTION; CARCINOMA; STOMACH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
M.D. Gammon et al., "TOBACCO, ALCOHOL, AND SOCIOECONOMIC-STATUS AND ADENOCARCINOMAS OF THEESOPHAGUS AND GASTRIC CARDIA", Journal of the National Cancer Institute, 89(17), 1997, pp. 1277-1284

Abstract

Background: Incidence rates for adenocarcinomas of the esophagus and gastric cardia have risen steeply over the last few decades, To determine risk factors for these tumors, we conducted a multicenter, population-based, case-control study, Methods: The study included 554 subjects newly diagnosed with esophageal or gastric cardia adenocarcinomas, 589 subjects newly diagnosed with esophageal squamous cell carcinoma orother gastric adenocarcinomas, and 695 control subjects. Estimates ofrisk (odds ratios [ORs] and corresponding 95% confidence intervals [CIs]) were calculated for the four tumor types separately and for esophageal and gastric cardia adenocarcinomas combined. Results: Risk of esophageal and gastric cardia adenocarcinomas combined was increased among current cigarette smokers (OR = 2.4; 95% = 1.7-3.4), with little reduction observed until 30 years after smoking cessation; this risk rose with increasing intensity and duration of smoking. Risk of these tumors was not related to beer (OR = 0.8; 95% CI = 0.6-1.1) or liquor (OR= 1.1; 95% CI = 0.8-1.4) consumption, but it was reduced for drinkingwine (OR = 0.6; 95% CI = 0.5-0.8), Similar ORs were obtained for the development of noncardia gastric adenocarcinomas in relation to tobacco and alcohol use, but higher ORs were obtained for the development ofesophageal squamous cell carcinomas, For all four tumor types, risks were higher among those with low income or education, Conclusions: Smoking is a major risk factor for esophageal and gastric cardia adenocarcinomas, accounting for approximately 40% of cases, Implications: Because of the long lag time before risk of these tumors is reduced among exsmokers, smoking may affect early stage carcinogenesis, The increasein smoking prevalence during the first two thirds of this century maybe reflected in the rising incidence of these tumors in the past few decades among older individuals, The recent decrease in smoking may not yet have had an impact.

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Documento generato il 24/09/20 alle ore 21:13:02