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Titolo:
PRETREATMENT WITH THE PROTEIN-KINASE-C ACTIVATOR PHORBOL 12,13-DIBUTYRATE ATTENUATES THE ETHANOL-INDUCED LOSS OF THE RIGHTING REFLEX IN MICE - MODIFICATION BY DIABETES
Autore:
OHSAWA M; KAMEI J;
Indirizzi:
HOSHI UNIV,FAC PHARMACEUT SCI,DEPT PATHOPHYSIOL & THERAPEUT,SHINAGAWAKU,4-41 EBARA 2 CHOME TOKYO 142 JAPAN HOSHI UNIV,FAC PHARMACEUT SCI,DEPT PATHOPHYSIOL & THERAPEUT,SHINAGAWAKU TOKYO 142 JAPAN
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 764, anno: 1997,
pagine: 244 - 248
SICI:
0006-8993(1997)764:1-2<244:PWTPAP>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
SHORT-SLEEP MICE; XENOPUS-OOCYTES; D-AMPHETAMINE; LONG-SLEEP; RATS; RESPONSES; DIACYLGLYCEROL; POTENTIATION; INHIBITION; MORPHINE;
Keywords:
ETHANOL; PROTEIN KINASE C; RIGHTING REFLEX; CALPHOSTIN C; PHORBOL 12,13-DIBUTYRATE; DIABETES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
M. Ohsawa e J. Kamei, "PRETREATMENT WITH THE PROTEIN-KINASE-C ACTIVATOR PHORBOL 12,13-DIBUTYRATE ATTENUATES THE ETHANOL-INDUCED LOSS OF THE RIGHTING REFLEX IN MICE - MODIFICATION BY DIABETES", Brain research, 764(1-2), 1997, pp. 244-248

Abstract

The effects of the protein kinase C (PKC) activator phorbol 12,13-dibutyrate (PDBu) on the ethanol-induced loss of the righting reflex werestudied in diabetic and non-diabetic mice. The ethanol-induced loss of the righting reflex was significantly less in diabetic mice than in non-diabetic mice. Intracerebroventricular (i.c.v.) pretreatment with PDBu dose-and time-dependently reduced the ethanol-induced loss of therighting reflex in non-diabetic mice. The reduction of the ethanol-induced loss of the righting reflex caused by PDBu was reversed by concomitant i.c.v. pretreatment with calphostin C, a selective PKC inhibitor. On the other hand, PDBu had no effect on the ethanol-induced loss of the righting reflex in diabetic mice. I.c.v. pretreatment with calphostin C (10 pmol) increased the ethanol-induced loss of the righting reflex in diabetic mice but not in non-diabetic mice. These results suggest that the activation of PKC reduces the ethanol-induced loss of the righting reflex in mice. Furthermore, it is possible that this attenuation of the ethanol-induced loss of the righting reflex in diabetic mice may be due in part to increased PKC activity. (C) 1997 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 23:10:47