Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ESTROGEN AS A NEUROMODULATOR OF MPTP-INDUCED NEUROTOXICITY - EFFECTS UPON STRIATAL DOPAMINE RELEASE
Autore:
DISSHON KA; DLUZEN DE;
Indirizzi:
NE OHIO UNIV,COLL MED,DEPT ANAT,4209 STATE ROUTE 44,POB 95 ROOTSTOWN OH 44272 NE OHIO UNIV,COLL MED,DEPT ANAT ROOTSTOWN OH 44272
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 764, anno: 1997,
pagine: 9 - 16
SICI:
0006-8993(1997)764:1-2<9:EAANOM>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARKINSONS-DISEASE; SUBSTANTIA NIGRA; C57/B1 MICE; CD-1 MICE; RAT; ESTRADIOL; INVITRO; BINDING; SEX; N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE;
Keywords:
NEUROTOXIN; NIGROSTRIATAL SYSTEM; DOPAMINE TRANSPORTER; PARKINSONS DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
K.A. Disshon e D.E. Dluzen, "ESTROGEN AS A NEUROMODULATOR OF MPTP-INDUCED NEUROTOXICITY - EFFECTS UPON STRIATAL DOPAMINE RELEASE", Brain research, 764(1-2), 1997, pp. 9-16

Abstract

The effects of estrogen upon MPTP-induced neurotoxicity were examinedusing in vitro superfusion. In Experiment 1, striatal tissue from ovariectomized rats was infused with MPP+ (10 mu M), a combination of MPP and 17 beta-estradiol (300 nM), the same dose of estradiol precedingMPP+, or no treatment infusion. The effects of these treatments on dopamine release rates during the infusion periods were determined. Infusion of MPP+ resulted in a significant increase in dopamine release ascompared to the control. Estradiol added to the MPP+ infusion significantly attenuated this dopamine (DA) release, while estradiol treatment preceding the MPP+ had no effect. In Experiment 2, three different doses of estradiol (0.3, 3, or 300 nM) were infused simultaneously withthe MPP+. Doses of estradiol below 300 nM did not attenuate the DA release. In Experiment 3, estradiol alone (300 nM) was infused, to determine dopamine release rate effects of the hormone itself. There was nodifference between estradiol treated and non-infused control groups. These results demonstrate that the gonadal steroid hormone estradiol can modulate responses of striatal dopamine neurons to MPP+ by alteringthe immediate increase in dopamine release which occurs in response to this neurotoxin. These modulating effects of estradiol are dose-dependent, and represent a direct effect upon striatal neurons, most likely involving a non-genomic mechanism of action. These results implicatethat hormonal modulation of nigrostriatal dopaminergic neurotoxicity may represent an important variable responsible for the sex differences which are reported in Parkinson's disease. (C) 1997 Elsevier ScienceB.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 20:15:38