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Titolo:
SLEEP CHANGES AFTER 4 CONSECUTIVE DAYS OF VENLAFAXINE ADMINISTRATION IN NORMAL VOLUNTEERS
Autore:
SALINPASCUAL RJ; GALICIAPOLO L; DRUCKERCOLIN R;
Indirizzi:
NATL AUTONOMOUS UNIV MEXICO,FAC MED,DEPT FISIOL,APDO POSTAL 70-250 MEXICO CITY 04510 DF MEXICO UNIV NACL AUTONOMA MEXICO,HOSP PSIQUIATR FRAY BERNARDINO ALVAREZ,SERVINVEST,SECRETARIA SALUD MEXICO CITY 04510 DF MEXICO UNIV NACL AUTONOMA MEXICO,INST FISIOL CELULAR,DEPT NEUROCIENCIAS MEXICO CITY 04510 DF MEXICO
Titolo Testata:
The Journal of clinical psychiatry
fascicolo: 8, volume: 58, anno: 1997,
pagine: 348 - 350
SICI:
0160-6689(1997)58:8<348:SCA4CD>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
R.J. Salinpascual et al., "SLEEP CHANGES AFTER 4 CONSECUTIVE DAYS OF VENLAFAXINE ADMINISTRATION IN NORMAL VOLUNTEERS", The Journal of clinical psychiatry, 58(8), 1997, pp. 348-350

Abstract

Background: The purpose was to examine the effect of the antidepressant drug venlafaxine on sleep architecture and periodic leg movements of sleep (PLMS) in normal volunteers. Method: Eight normal volunteers were studied under laboratory sleep conditions as follows: 1 acclimatization night, 1 baseline night, and 4 consecutive nights of venlafaxinep.o. administration (75 mg during the first 2 nights and 150 mg the last 2 nights). Results: Venlafaxine increased both wake time and sleepstage I. Sleep stages II and III were reduced. REM sleep time was reduced after the first venlafaxine dose, and, by the fourth night, REM sleep was completely suppressed in all volunteers. Six of the eight volunteers showed PLMS at a frequency above 25 per hour. Conclusion: Venlafaxine produces several sleep disturbances, which include abnormal leg movements.

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Documento generato il 04/04/20 alle ore 08:56:26