Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
EVALUATION OF THE REINFORCING EFFECTS OF ELIPRODIL IN RHESUS-MONKEYS AND ITS DISCRIMINATIVE STIMULUS EFFECTS IN RATS
Autore:
BALSTER RL; NICHOLSON KL; SANGER DJ;
Indirizzi:
VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT PHARMACOL & TOXICOLRICHMOND VA 23298 SYNTHELABO RECH F-92220 BAGNEUX FRANCE
Titolo Testata:
Drug and alcohol dependence
fascicolo: 3, volume: 35, anno: 1994,
pagine: 211 - 216
SICI:
0376-8716(1994)35:3<211:EOTREO>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
ASPARTATE RECEPTOR ANTAGONIST; ANTI-ISCHEMIC AGENTS; PHENCYCLIDINE-LIKE; IFENPRODIL; SL-82.0715; COMPLEX; MK-801; BRAIN;
Keywords:
ELIPRODIL; PCP; DIZOCILPINE; NMDA RECEPTOR; SELF-ADMINISTRATION; DRUG DISCRIMINATION; RHESUS MONKEYS; RATS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
R.L. Balster et al., "EVALUATION OF THE REINFORCING EFFECTS OF ELIPRODIL IN RHESUS-MONKEYS AND ITS DISCRIMINATIVE STIMULUS EFFECTS IN RATS", Drug and alcohol dependence, 35(3), 1994, pp. 211-216

Abstract

Two studies examined the abuse potential of the N-methyl-D-aspartate (NMDA) non-competitive antagonist eliprodil alpha-(4-chlorophenyl)-4-[(fluorophenyl)methyl]-1- piperidineethanol] by evaluating its reinforcing effects in rhesus monkeys and its phencyclidine (PCP)-like discriminative stimulus effects in rats. The monkeys were trained to self-administer PCP i.v. under a fixed ratio 10 schedule of reinforcement. After the monkeys were trained, saline, vehicle and various doses of eliprodil were substituted for PCP. The rats were trained to discriminate 3 mu g/kg PCP from saline using a standard two-lever discrimination procedure with correct-lever responding reinforced under a fixed ratio 10 schedule of food reinforcement. After acquiring the discrimination, the rats were tested with various doses of PCP, dizocilpine and eliprodil. The self-administration study showed that eliprodil did not have reinforcing effects, since it maintained injection rates comparable tothe negative controls, saline and vehicle. In the discrimination study it was found that the higher doses of PCP and dizocilpine resulted in 100% PCP-associated lever responding, whereas eliprodil occasioned no responding on the PCP-associated lever. The results from these studies suggest that eliprodil has a low potential for abuse in humans as well as providing further evidence that eliprodil produces a profile ofbehavioral effects unlike the PCP-site selective NMDA antagonists.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 03:19:00