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Titolo:
REGULATION OF EXPRESSION AND FUNCTION OF M2 AND M4 MUSCARINIC RECEPTORS IN CULTURED EMBRYONIC CHICK HEART-CELLS BY TRANSFORMING GROWTH FACTOR-BETA(1)
Autore:
JACKSON DA; NATHANSON NM;
Indirizzi:
UNIV WASHINGTON,DEPT PHARMACOL,BOX 357750 SEATTLE WA 98195 UNIV WASHINGTON,DEPT PHARMACOL SEATTLE WA 98195
Titolo Testata:
Biochemical pharmacology
fascicolo: 4, volume: 54, anno: 1997,
pagine: 525 - 527
SICI:
0006-2952(1997)54:4<525:ROEAFO>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR-BETA; CARDIAC MYOCYTES; GENE-EXPRESSION;
Keywords:
MUSCARINIC ACETYLCHOLINE RECEPTOR; CARDIAC CELL CULTURE; GROWTH FACTOR; MESSENGER-RNA; CAMP; SIGNAL TRANSDUCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
D.A. Jackson e N.M. Nathanson, "REGULATION OF EXPRESSION AND FUNCTION OF M2 AND M4 MUSCARINIC RECEPTORS IN CULTURED EMBRYONIC CHICK HEART-CELLS BY TRANSFORMING GROWTH FACTOR-BETA(1)", Biochemical pharmacology, 54(4), 1997, pp. 525-527

Abstract

Incubation of cultured embryonic chicken heart cells with transforming growth factor beta(1) (TGF-beta(1)) resulted in a concentration-and time-dependent decrease in the number of muscarinic acetylcholine receptors (mAChR), which reached a maximum by 24 hr. Twenty-four hours following TGF-beta(1) treatment, cm2 and cm4 mAChR protein levers were decreased 59 and 41%, respectively, and cm2 mRNA and cm4 mRNA levels were both decreased by approximately 40%. Chick heart cells treated with TGF-beta(1) exhibited a decreased sensitivity for carbachol-mediated inhibition of adenylyl cyclase activity compared with control cells. Thus, TGF-beta(1) stimulation of chick heart cells results in decreases in the expression of both cm2 and cm4 mAChR and in muscarinic responsiveness. (C) 1997 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/11/20 alle ore 21:40:21