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Titolo:
INFLUENCE OF THE DOPAMINE D2 RECEPTOR (DRD2) GENOTYPE ON NEUROADAPTIVE EFFECTS OF ALCOHOL AND THE CLINICAL OUTCOME OF ALCOHOLISM
Autore:
FINCKH U; ROMMELSPACHER H; KUHN S; DUFEU P; OTTO G; HEINZ A; DETTLING M; GIRALDOVELASQUEZ M; PELZ J; GRAF KJ; HARMS H; SANDER T; SCHMIDT LG; ROLFS A;
Indirizzi:
UNIV HAMBURG,KRANKENHAUS EPPENDORF,INST HUMAN GENET,BUTENFELD 42 D-22529 HAMBURG GERMANY FREE UNIV BERLIN,WORKING GRP MOL NEUROBIOL,INST NEUROPSYCHOPHARMACOL,HOSP BENJAMIN FRANKLIN D-1000 BERLIN GERMANY FREE UNIV BERLIN,HOSP BENJAMIN FRANKLIN,DEPT PSYCHIAT D-1000 BERLIN GERMANY HUMBOLDT UNIV BERLIN,VIRCHOW CLIN,INST HUMAN GENET BERLIN GERMANY HUMBOLDT UNIV BERLIN,VIRCHOW CLIN,DEPT INTERNAL MED BERLIN GERMANY UNIV HOSP ROSTOCK,DEPT NEUROL ROSTOCK GERMANY
Titolo Testata:
Pharmacogenetics
fascicolo: 4, volume: 7, anno: 1997,
pagine: 271 - 281
SICI:
0960-314X(1997)7:4<271:IOTDDR>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE DRD2; A1 ALLELE; STRUCTURAL POLYMORPHISM; BINDING CHARACTERISTICS; D2-DOPAMINE RECEPTOR; NUCLEUS-ACCUMBENS; ASSOCIATION; HAPLOTYPES; WITHDRAWAL; PCR;
Keywords:
DOPAMINE D2 RECEPTOR; POLYMORPHISM; DRD2; ALCOHOLISM; APOMORPHINE; WITHDRAWAL; DEPRESSIVENESS; ANXIETY; SUICIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
U. Finckh et al., "INFLUENCE OF THE DOPAMINE D2 RECEPTOR (DRD2) GENOTYPE ON NEUROADAPTIVE EFFECTS OF ALCOHOL AND THE CLINICAL OUTCOME OF ALCOHOLISM", Pharmacogenetics, 7(4), 1997, pp. 271-281

Abstract

The present study was performed to test the hypotheses that allelic variants at the human dopamine D2 receptor gene locus (DRD2) confer susceptibility to alcoholism or are associated with clinical subtypes of alcoholism, We investigated an A --> G substitution polymorphism in the 3'-untranslated region of exon 8 (E8) of DRD2 with allele frequencies of f(G) = 0.295 - 0.329. No significant association of the DRD2 genotype or allele frequencies with alcoholism was found in an associationstudy including 283 alcoholics and 146 non-alcoholic controls, However, the frequent homozygous E8 A/A genotype with f(AA) = 0.47 - 0.48 was associated with increased anxiety and depression scores in alcoholics during the follow up after clinical detoxification treatment. In addition, E8 A/A was associated with increased suicide attempts and showed a tendency towards more severe withdrawal symptoms, early relapse and reduced responsiveness to the dopaminergic agonist apomorphine, Regression analysis revealed the DRD2 E8 genotype as the only significant factor determining withdrawal severity in female alcoholics, The findings suggest an influence of the DRD2 genotype on the neuropharmacological effects of chronic alcohol exposure and the clinical course of alcoholism.

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Documento generato il 29/03/20 alle ore 01:37:05