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Titolo:
BASIC SCIENCE ASPECTS OF PROSTATE-CANCER
Autore:
DORKIN TJ; NEAL DE;
Indirizzi:
UNIV NEWCASTLE UPON TYNE,SCH SURG SCI,SCH MED,FRAMLINGTON PL NEWCASTLE TYNE NE1 7RU TYNE & WEAR ENGLAND FREEMAN RD HOSP NEWCASTLE TYNE NE7 7DN TYNE & WEAR ENGLAND
Titolo Testata:
Seminars in cancer biology
fascicolo: 1, volume: 8, anno: 1997,
pagine: 21 - 27
SICI:
1044-579X(1997)8:1<21:BSAOP>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPIDERMAL GROWTH-FACTOR; ANDROGEN-RECEPTOR GENE; P53 PROTEIN ACCUMULATION; TGF-BETA RECEPTOR; CELL-LINES; MESSENGER-RNA; TRANSFORMING GROWTH-FACTOR-BETA-1; IMMUNOHISTOCHEMICAL LOCALIZATION; EPITHELIAL-CELLS; FACTOR-VIII;
Keywords:
ANDROGEN; ANDROGEN RECEPTOR; GROWTH FACTORS; PROSTATE CANCER; STEM CELL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
60
Recensione:
Indirizzi per estratti:
Citazione:
T.J. Dorkin e D.E. Neal, "BASIC SCIENCE ASPECTS OF PROSTATE-CANCER", Seminars in cancer biology, 8(1), 1997, pp. 21-27

Abstract

Prostate cancer carries significant morbidity and mortality, but its outcome is difficult to predict in the individual. Androgen ablation delays progression in men, but hormone resistance soon develops and much basic science research has focused on how prostate cancer 'escapes' hormonal control. Stem cell models of prostate development and homeostasis have been proposed, but have not yet been fully characterized. Some androgen-regulated signalling pathways and abnormalities that affect them have been defined recently. It is apparent that locally produced growth factors, often regulated by androgens, exert an effect both physiologically and pathologically and these too will be discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/21 alle ore 15:09:25