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Titolo:
THE ROLE OF MAGNESIUM IN THE PATHOGENESIS OF BONE-DISEASE IN CHILDHOOD CHOLESTATIC LIVER-DISEASE - A PRELIMINARY-REPORT
Autore:
HEUBI JE; HIGGINS JV; ARGAO EA; SIERRA RI; SPECKER BL;
Indirizzi:
CHILDRENS HOSP,MED CTR,CLIN RES CTR,DIV PEDIAT GASTROENTEROL & NUTR,3333 BURNET AVE CINCINNATI OH 45229 CHILDRENS HOSP,MED CTR,PEDIAT BONE RES CTR CINCINNATI OH 45229 CHILDRENS HOSP,MED CTR,GEN CLIN RES CTR CINCINNATI OH 45229
Titolo Testata:
Journal of pediatric gastroenterology and nutrition
fascicolo: 3, volume: 25, anno: 1997,
pagine: 301 - 306
SICI:
0277-2116(1997)25:3<301:TROMIT>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
VITAMIN-D; CALCIUM-ABSORPTION; BILIARY ATRESIA; 1,25-DIHYDROXYVITAMIN-D; SERUM; METABOLISM; EXTRACTION; DEFICIENCY; CHILDREN; ASSAY;
Keywords:
BONE MINERAL DENSITY; BONE MINERALIZATION; CHOLESTASIS; MAGNESIUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
J.E. Heubi et al., "THE ROLE OF MAGNESIUM IN THE PATHOGENESIS OF BONE-DISEASE IN CHILDHOOD CHOLESTATIC LIVER-DISEASE - A PRELIMINARY-REPORT", Journal of pediatric gastroenterology and nutrition, 25(3), 1997, pp. 301-306

Abstract

Background: Magnesium deficiency may contribute to the metabolic bonedisease that complicates chronic cholestatic liver disease. We hypothesized that magnesium deficiency alters vitamin D metabolism by decreasing parathyroid hormone (PTH) response, resulting in decreased serum osteocalcin and decreased bone accretion. Methods: Nine subjects, age 3-22 years, with cholestatic liver disease were evaluated with the magnesium retention test. The response of PTH, 1,25(OH)(2) vitamin D, andosteocalcin to provocative stimuli and dual x-ray absorptiometry measurement of bone mineral density (BMD) of the lumbar spine were assessed. Thereafter, subjects were treated with oral magnesium supplements. Results: All nine subjects were magnesium depleted. Repletion with magnesium was successful in seven subjects, and required 4 to 31 (median 14) months with doses of 6 to 34 (median 11) mg/kg/day. Baseline serumPTH was significantly reduced in the cholestatic subjects compared to15 age-matched controls. Comparison of baseline to repleted provocative testing was performed in six Mg-repleted subjects. Osteocalcin response increased significantly (p = 0.048) with repletion, while PTH response increased (p = 0.061). Lumbar spine BMD increased modestly with repletion (p = 0.093). Conclusions: This preliminary report suggests that magnesium depletion is extremely common in children with chronic cholestasis. We speculate that magnesium supplementation may be warranted to forestall the progression of metabolic bone disease in chronic cholestasis. (C) 1997 Lippincott-Raven Publishers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 21:41:36