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Titolo:
DIVERGENCE OF THE YELLOW GENE BETWEEN DROSOPHILA-MELANOGASTER AND D-SUBOBSCURA - RECOMBINATION RATE, CODON BIAS AND SYNONYMOUS SUBSTITUTIONS
Autore:
MUNTE A; AGUADE M; SEGARRA C;
Indirizzi:
UNIV BARCELONA,FAC BIOL,DEPT GENET,DIAGONAL 645 E-08071 BARCELONA SPAIN UNIV BARCELONA,FAC BIOL,DEPT GENET E-08071 BARCELONA SPAIN
Titolo Testata:
Genetics
fascicolo: 1, volume: 147, anno: 1997,
pagine: 165 - 175
SICI:
0016-6731(1997)147:1<165:DOTYGB>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOLECULAR EVOLUTION; X-CHROMOSOME; NUCLEOTIDE SUBSTITUTIONS; DELETERIOUS MUTATIONS; REGULATORY ELEMENTS; CENTROMERIC REGION; NATURAL-SELECTION; OBSCURA GROUP; SILENT SITES; DNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
59
Recensione:
Indirizzi per estratti:
Citazione:
A. Munte et al., "DIVERGENCE OF THE YELLOW GENE BETWEEN DROSOPHILA-MELANOGASTER AND D-SUBOBSCURA - RECOMBINATION RATE, CODON BIAS AND SYNONYMOUS SUBSTITUTIONS", Genetics, 147(1), 1997, pp. 165-175

Abstract

The yellow (y) gene maps near the telomere of the X chromosome in Drosophila melanogasta but not in D. subobscura. Thus the strong reduction in the recombination rate associated with telomeric regions is not expected in D. subobscura. To study the divergence of a gene whose recombination rate differs between two species, the y gene of D. subobscura was sequenced. Sequence comparison between D. melanogaster and D. subobscura revealed several elements conserved in noncoding regions thatmay correspond spend to putative cis-acting regulatory sequences. Divergence in the y gene coding region between D. subobscura and D. melanogaster was compared with that found in other genes sequenced in both species. Both, yellow and scute exhibit an unusually high number of synonymous substitutions per site (p(s)). Also for these genes, the extent of codon bias differs between both species, being much higher in D.subobscura than in D. melanogaster. This pattern of divergence is consistent with the hitchhiking and background selection models that predict an increase in the fixation rate of slightly deleterious mutationsand a decrease in the rate of fixation of slightly advantageous mutations in regions with low recombination rates such as in the y-sc gene region of D. melanogaster.

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Documento generato il 29/11/20 alle ore 07:04:31