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Titolo:
INSULIN-STIMULATED GLYCOGEN-SYNTHESIS IN ISOLATED RAT HEPATOCYTES - EFFECT OF PROTEIN-KINASE INHIBITORS
Autore:
CARLSEN J; CHRISTIANSEN K; VINTEN J;
Indirizzi:
UNIV COPENHAGEN,PANUM INST,DEPT MED BIOCHEM & GENET,BLEGDAMSVEJ 3 DK-2200 COPENHAGEN N DENMARK UNIV COPENHAGEN,PANUM INST,DEPT MED PHYSIOL DK-2200 COPENHAGEN N DENMARK
Titolo Testata:
Cellular signalling
fascicolo: 6, volume: 9, anno: 1997,
pagine: 447 - 450
SICI:
0898-6568(1997)9:6<447:IGIIRH>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHOSPHATIDYLINOSITOL 3-KINASE; GLUCOSE-TRANSPORT; SYNTHASE KINASE-3; SKELETAL-MUSCLE; WORTMANNIN; ACTIVATION; RAPAMYCIN; CELLS; ADIPOCYTES; MECHANISMS;
Keywords:
HEPATOCYTES; GLYCOGEN SYNTHESIS; INSULIN; PI 3-KINASE; P70-S6 KINASE; MAP KINASE KINASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
J. Carlsen et al., "INSULIN-STIMULATED GLYCOGEN-SYNTHESIS IN ISOLATED RAT HEPATOCYTES - EFFECT OF PROTEIN-KINASE INHIBITORS", Cellular signalling, 9(6), 1997, pp. 447-450

Abstract

Glycogen synthesis was studied in rat hepatocytes isolated by EDTA perfusion. Insulin induced a one and a half to twofold increase in glucose incorporation into glycogen. Insulin stimulated glycogen synthesis was inhibited by the phosphatidylinositol 3-kinase inhibitors wortmannin (IC50 similar to 40 nM) and LY 294002 (IC50 similar to 20 mu M) andthe mitogen-activated protein kinase kinase inhibitor PD 98059 (IC50 similar to 40 mu M). Wortmannin was without appreciable effect on non-insulin stimulated glycogen synthesis, while LY 294002 and PD 98059 also inhibited the non insulin stimulated glycogen synthesis. Rapamycin,an inhibitor of p70 ribosomal protein-S6 kinase, was without effect on glycogen synthesis regardless of insulin stimulation. (C) 1997 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 21:18:30