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Titolo:
ACELLULAR PERTUSSIS-VACCINE IN CHILDREN WITH PERINATAL HUMAN-IMMUNODEFICIENCY-VIRUS-TYPE-1 INFECTION
Autore:
DEMARTINO M; PODDA A; GALLI L; SINANGIL F; MANNELLI F; ROSSI ME; VIERUCCI A;
Indirizzi:
UNIV CHIETI,DEPT MED,SECT PEDIAT,VIA COLLE ARA I-66100 CHIETI ITALY CHIRON VACCINES I-53100 SIENA ITALY UNIV FLORENCE,DEPT PEDIAT I-50133 FLORENCE ITALY
Titolo Testata:
Vaccine
fascicolo: 11, volume: 15, anno: 1997,
pagine: 1235 - 1238
SICI:
0264-410X(1997)15:11<1235:APICWP>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
PNEUMOCOCCAL VACCINE; ANTIBODY-RESPONSE; INFANTS; IMMUNOGENICITY; TETANUS; TRIAL;
Keywords:
ACELLULAR PERTUSSIS VACCINE; HIV-1 PERINATAL INFECTION; IMMUNIZATION; PERTUSSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
M. Demartino et al., "ACELLULAR PERTUSSIS-VACCINE IN CHILDREN WITH PERINATAL HUMAN-IMMUNODEFICIENCY-VIRUS-TYPE-1 INFECTION", Vaccine, 15(11), 1997, pp. 1235-1238

Abstract

The immunogenicity of an acellular pertussis vaccine containing genetically detoxified pertussis toxin, filamentous haemoagglutinin and pertactin was studied in 12 children [median age, 45 (6-107) months] withperinatal human immunodeficiency virus-type I (HIV-I) infection, Antibody response to all antigens was observed in six cases and another children 3 reacted to two or one antigen(s), but titres were lower than those from healthy controls, Antibody title fold-rise correlated with preimmunization CD4-positive cell counts, Significant titles were still detectable 4 months after the third nose, The acellular vaccine is immunogenic in a portion of children with perinatal HIV-I infection butearly vaccination might be mole effective, taking advantage of still adequate CD4-positive cell numbers. (C) 1997 Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 04:35:36