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Titolo:
ELECTROPHYSIOLOGICAL EVIDENCE FOR A FUNCTIONAL INTERACTION BETWEEN 5-HT1A AND 5-HT2A RECEPTORS IN THE RAT MEDIAL PREFRONTAL CORTEX - AN IONTOPHORETIC STUDY
Autore:
ASHBY CR; EDWARDS E; WANG RY;
Indirizzi:
SUNY STONY BROOK,DEPT PSYCHIAT & BEHAV SCI,PUTNAM HALL S CAMPUS STONYBROOK NY 11794 SUNY STONY BROOK,DEPT PSYCHIAT & BEHAV SCI STONY BROOK NY 11794 BROOKHAVEN NATL LAB,DEPT MED UPTON NY 11973 UNIV MARYLAND BALTIMORE MD 21201
Titolo Testata:
Synapse
fascicolo: 3, volume: 17, anno: 1994,
pagine: 173 - 181
SICI:
0887-4476(1994)17:3<173:EEFAFI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN RECEPTORS; BEHAVIORAL EVIDENCE; BRAIN; LOCALIZATION; NUCLEUS; 5-HYDROXYTRYPTAMINE2; 5-HT2-RECEPTOR; RESPONSES; SUBTYPES; AGONIST;
Keywords:
MEDIAL PREFRONTAL CORTEX; 5-HT1A RECEPTORS; 5-HT2 RECEPTORS; MICROIONTOPHORESIS; ELECTROPHYSIOLOGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
C.R. Ashby et al., "ELECTROPHYSIOLOGICAL EVIDENCE FOR A FUNCTIONAL INTERACTION BETWEEN 5-HT1A AND 5-HT2A RECEPTORS IN THE RAT MEDIAL PREFRONTAL CORTEX - AN IONTOPHORETIC STUDY", Synapse, 17(3), 1994, pp. 173-181

Abstract

In this study, we examined the interaction of 5-HT1A and 5-HT2A receptors in the rat medial prefrontal cortex (mPFc) using the techniques of extracellular single unit recording and microiontophoresis. The iontophoresis of the selective 5-HT1A receptor agonist (+/-)-8-hydroxy-2-(di-n-propylamino) tetralin (8-OHDPAT) produced a current-dependent suppression (2.5-20 nA) of the basal firing rate of spontaneously active mPFc cells. The iontophoretic (5-10 nA) and systemic administration (0.1-0.5 mg/kg, i.v.) of the 5-HT2A/5-HT2C receptor antagonist ritanserin and the selective 5-HT2A receptor antagonist MDL 28727 significantlypotentiated and prolonged 8-OHDPAT's suppressant action. In addition,the systemic administration of another selective 5-HT2A antagonist MDL 100907, but not its less active enantiomer MDL 100009, also potentiated and prolonged 8-OHDPAT's action. The potentiating effect of the 5-HT2A receptor antagonists on the action of 8-OHDPAT is specific in that neither the iontophoresis of ritanserin nor MDL 28727 altered the suppressant action produced by the iontophoresis of the 5-HT3 receptor agonist 2-methylserotonin onto mPFc cells. Moreover, the suppressant action of 8-OHDPAT was not altered by the systemic administration of theselective 5-HT3 receptor antagonist granisetron (0.1-0.5 mg/kg, i.v.). On the other hand, the iontophoresis of a low current (0.5 nA) of the 5-HT2A,2C receptor agonist +/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) potentiated the excitation induced by the iontophoresis of 1-glutamate on quiescent mPFc cells. The iontophoresis of 8-OHDPAT at a current that had no effect on the firing rate of 1-glutamate activated when administered alone significantly attenuated the excitatory action produced by the iontophoresis of DOI. Overall, these results confirm and extend the hypothesis that there is an interaction between5-HT1A and 5-HT2A receptors in the mPFc at the neuronal level. (C) 1994 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 06:07:05