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Titolo:
CONTIGUOUS ARRAYS OF SATELLITE-1, SATELLITE-3, AND SATELLITE-BETA FORM A 1.5-MB DOMAIN ON CHROMOSOME 22P
Autore:
SHIELS C; COUTELLE C; HUXLEY C;
Indirizzi:
ST MARYS HOSP,IMPERIAL COLL SCH MED,DEPT BIOCHEM & MOL GENET,NORFOLK PL LONDON W2 1PG ENGLAND ST MARYS HOSP,IMPERIAL COLL SCH MED,DEPT BIOCHEM & MOL GENET LONDON W2 1PG ENGLAND
Titolo Testata:
Genomics
fascicolo: 1, volume: 44, anno: 1997,
pagine: 35 - 44
SICI:
0888-7543(1997)44:1<35:CAOSSA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-SITU HYBRIDIZATION; HUMAN ACROCENTRIC CHROMOSOMES; HUMAN Y-CHROMOSOME; INSITU HYBRIDIZATION; REPETITIVE DNA; PERICENTROMERIC REGION; SEQUENCE DEFINITION; LOCALIZATION; ORGANIZATION; REPEAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
C. Shiels et al., "CONTIGUOUS ARRAYS OF SATELLITE-1, SATELLITE-3, AND SATELLITE-BETA FORM A 1.5-MB DOMAIN ON CHROMOSOME 22P", Genomics, 44(1), 1997, pp. 35-44

Abstract

The centromeric heterochromatin of all the human chromosomes is composed of megabases of tandemly repeated satellite DNA, Some of these sequences have been implicated in centromere formation and/or segregationbut the arrangement of most of them on a large scale remains largely uncharacterized because of the difficulties in analyzing repetitive DNA. The alpha satellite is the best studied and is present in large tandem arrays at all centromeres, but satellites 1, 3, and beta have alsobeen detected on a number of chromosomes. Here we have used FISH to extended DNA fibers to analyze these satellites on the short arm of theacrocentric chromosome 22. The satellite sequences were found to forma continuous domain spanning about 1.5 Mb and consisting of a major block of satellite 1 flanked by two blocks of beta satellite and three blocks of satellite 3. These six blocks of satellite DNA appear to form contiguous arrays with little intervening DNA. (C) 1997 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 11:14:21